margin of safety

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margin

 [mahr´jin]
an edge or border.
gingival margin gum margin.
gum margin the border of the gingiva surrounding, but unattached to, the substance of the teeth.
margin of safety a calculation that takes the highest animal no observed adverse effect level and estimates a maximum safe level of exposure for humans. It is now generally superseded by the reference dose.

mar·gin of safe·ty

the range between the minimal therapeutic dose and the minimal toxic dose of a drug.

margin of safety

an index of a drug's effectiveness and safety. It is calculated as the amount of drug that is lethal to 1% of animals (LD1) divided by the amount of drug that causes a beneficial effect in 99% of the animals (ED99). See also dose-response relationship.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The area between the minimal therapeutic dose and the minimal toxic dose of a drug.
Synonym(s): safety margin.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The gap (i.e., range) between the minimal therapeutic dose of a drug and its minimal toxic dose.
References in periodicals archive ?
The amount of resources expended on maintaining a well-trained Safety staff is usually much less but it informs every term in the safety margin equation above.
where Z--the random safety margin by Eq (1) and Eq (3); H > 0--the event of visual and nondestructive inspection results showing a successful opposition of members to unforeseen extreme action effects.
The coefficient of correlation of rank safety margin cuts is calculated from the equation
At about 50 dBA, the average safety margin becomes low enough to cause concern about detectability.
Even with modern biphasic ICDs, inadequate safety margin (>10 J) has been reported in up to 6.
12) Nevertheless, even though our patient had no evidence of either, we decided to irradiate the primary tumor site because the safety margin of the excised sarcoma was small.
As Martin-Lof notes, "This is a safety margin which we consider integral to our acquisition strategy.
Foundry engineers tested the usefulness of casting simulation by producing a steel casting with a higher safety margin, less turbulent filling and improved yield.
By remaining inventive and adapting quickly to the existing circumstances, officers can bolster their effectiveness and at the same time widen the situation's safety margin.
Featuring improved thermal stability and lower shutdown temperature for a higher safety margin, the developmental grades add to the company's battery separator film portfolio that includes the award-winning V-series separator films introduced in 2007.
While the station may have briefly experienced accelerations that exceeded seismic accelerations to which it was originally licensed, its multiple layers of strength and safety provided a safety margin that was not exceeded.
Traditionally, a safety margin of at least 10 J between the maxi mum output of the pulse generator and the energy needed for defibrillation has been used because early studies indicate that lower safety margins were associated with high rates of failed defibrillation and sudden cardiac death (7,8).