margin of safety (redirected from safety margin)

margin of safety

n.

The amount between a therapeutic dose and a lethal dose of a drug.

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margin of safety,

an index of a drug's effectiveness and safety. It is calculated as the amount of drug that is lethal to 1% of animals (LD₁) divided by the amount of drug that causes a beneficial effect in 99% of the animals (ED₉₉). See also dose-response relationship.

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margin [mahr´jin]

an edge or border.

gingival margin gum margin.

gum margin the border of the gingiva surrounding, but unattached to, the substance of the teeth.

margin of safety a calculation that takes the highest animal no observed adverse effect level and estimates a maximum safe level of exposure for humans. It is now generally superseded by the reference dose.

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margin,

n 1. the extreme edge of something.
n 2. the boundary of a surface.
n 3. in a cavity preparation for a restoration, the margin is the outside limit of the surgical preparation. See also cavosurface angle.

margin, bone,

n the peripheral edge of a bone.

(kā´vōsur´fs),
n the point of contact between a tooth surface and the face of an associated cavity.

margin, enamel,

n the part of the margin of a preparation that is laid in enamel.

margin, free gingival,

n See margin, gingival.

margin, gingival,

n 1. the cavosurface angle of the wall of a cavity preparation closest to the apex of the root.
n 2. the crest or tip of the gingival tissues that forms the wall ofthe gingival sulcus. Also called
free gingival margin or
gingival crest.

margin of safety,

n the margin between lethal and toxic doses.

margin, thickened bone,

n See bone, thickened margin of.