Certain substances, such as sFlt-1
, are elevated in preeclampsia and are believed to contribute to disease progression and severity.
Diagnostic solutions include the Roche cobas cTnT-hs test, which offers a high diagnostic accuracy for acute myocardial infarction (AMI), a major cause of death and disability worldwide; Elecsys sFlt-1
and PIGF for pre-eclampsia diagnosis and other types of hypertensive disorders; and the cobas EGFR test, help determine whether patients with non-small-cell lung carcinoma (NSMLC) carry epidermal growth factor receptor (EGFR) mutations.
Presented at the 18th World Congress on Controversies in Obstetrics, Gynecology & Infertility (COGI) held in Vienna in October, the study is investigating the correlation between the ratio of two proteins sFlt-1
(soluble fms-like tyrosine kinase-1) and PlGF (placental growth factor) in maternal blood and the risk of developing preeclampsia over the subsequent four weeks.
Previous studies have demonstrated elevated blood sFlt-1
levels or reduced blood PlGF levels in women whose pregnancies were complicated by intrauterine growth restriction, preeclampsia, and gestational hypertension (Asvold et al.
protein is a truncated form of the VEGF receptor Flt-1, lacking the transmembrane and the intracytoplasmic domains and therefore secreted extracellularly (18).
Circulating levels of sFlt-1
are increased in pre-eclampsia and particularly the early onset form of the disease, resulting in reduced levels of free VEGF-A and P1GF in the maternal circulation.
But both the level of vitamin D and the ratio of sFlt-1
to PlGF predicted the development of severe preeclampsia after other risk factors were taken into account.
Ucuncu arastirmada ise, preeklamptik anne bebeklerinin kordon kaninda, sFlt-1
duzeyinin yuksek, PIGF ve VEGF duzeylerinin dusuk oldugu gosterilmistir (25).
About the role of PIGF, sFlt-1
, sCD40L and PAPP-A in cardiovascular disease
His prior work with sFlt-1
and his expertise in translational research make him exceptionally valuable as an advisor and research collaborator," explains Dr.
is thought to be able to capture PlGF and thereby reduce the amount available to bind to the receptor located on macrophages and endothelial cells (11).
The combination of sFlt-1
and PlGF is particularly important for the prognosis of patients with angina pectoris and after myocardial infarction.