ryanodine receptor 2

ryanodine receptor 2

A membrane calcium-channel receptor encoded by RYR2 on chromosome 1q43, which is found in cardiac muscle sarcoplasmic reticulum and required for excitation-contraction coupling in cardiac muscle.

Function
Responsible for communication between transverse-tubules (T-tubules) and sarcoplasmic reticulum (SR), resulting in cardiac muscle contraction triggered by Ca2+ release from SR following T-tubule depolarization.

Abnormal in
Stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.