ryanodine receptor


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ryanodine receptor

receptor associated with a calcium conductance channel in the sarcoplasmic or endoplasmic reticulum of cells, which when bound to ryanodine, causes the channel to remain in a subconductive state, allowing slow continuing release of calcium ions from the sarcoplasmic reticulum into the cytoplasm. The channels are normally sensitive to calcium ions and not sensitive to inositol triphosphate.

ry·an·o·dine re·cep·tor

(rī-an'ō-dēn rĕ-sep'tŏr)
Receptor associated with a calcium conductance channel in the sarcoplasmic or endoplasmic reticulum of cells, which, when bound to ryanodine, causes the channel to remain in a subconductive state, allowing slow continuing release of calcium ions from the sarcoplasmic reticulum into the cytoplasm. The channels are normally sensitive to calcium ions and not sensitive to inositol triphosphate.

ryanodine receptor

Abbreviation: RyR
The release channel for calcium ions that is found on the membranes of the sarcoplasmic reticulum of skeletal muscles.
See also: receptor
References in periodicals archive ?
Malignant hyperthermia susceptibility diagnosed with a family-specific ryanodine receptor gene type 1 mutation.
Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia.
2+] is released from the SR through activation of ryanodine receptors.
A novel ryanodine receptor mutation and genotypephenotype correlation in a large malignant hyperthermia New Zealand Maori pedigree.
1991) demonstrated that a mutation of ryanodine receptor (locus ryr-1) causes malignant hyperthermia in pigs, which leads to PSE meat, numerous studies have been launched into the field of genetic background and major gene identification for meat quality.
The researcher has revealed that the team were able to stop the harmful effects of Tat in neurons from mice by using the drug dantrolene, which blocks the ryanodine receptor.
Phenotypes with less strong contracture tests have mutations on other genes coding for different parts of the ryanodine receptor complex.
Genetic mutations in the Ryanodine receptor lead to abnormally high levels of calcium which interfere with the heart rhythm and can result in sudden death.
The company's proprietary drugs, known as Rycals (TM), are a new class of oral agents that repair calcium leak through the ryanodine receptor calcium-release channel (RyR), which is located on the sarcoplasmic/endoplasmic reticulum of the cell.
KEY WORDS: dendrites, developmental neurotoxicity, hippocampal neurons, neuronal connectivity, non-dioxin-like PCBs, ryanodine receptor.
Not only has more than one gene been linked to MH in association studies (2), but over 180 mutations have been identified in the skeletal muscle ryanodine receptor gene (RYR1), the gene most commonly linked to MH (6,7).
a biopharmaceutical company developing innovative small molecule drugs known as "Rycals (TM)," which act on the ryanodine receptor calcium-release channel (RyR), announced that a study published today in the prestigious scientific journal Cell reveals the underlying role of calcium leak through the RyR as an important contributor to stress-induced cognitive dysfunction.