ryanodine receptor


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Related to ryanodine receptor: ryanodine receptor 1

ryanodine receptor

receptor associated with a calcium conductance channel in the sarcoplasmic or endoplasmic reticulum of cells, which when bound to ryanodine, causes the channel to remain in a subconductive state, allowing slow continuing release of calcium ions from the sarcoplasmic reticulum into the cytoplasm. The channels are normally sensitive to calcium ions and not sensitive to inositol triphosphate.

ry·an·o·dine re·cep·tor

(rī-an'ō-dēn rĕ-sep'tŏr)
Receptor associated with a calcium conductance channel in the sarcoplasmic or endoplasmic reticulum of cells, which, when bound to ryanodine, causes the channel to remain in a subconductive state, allowing slow continuing release of calcium ions from the sarcoplasmic reticulum into the cytoplasm. The channels are normally sensitive to calcium ions and not sensitive to inositol triphosphate.

ryanodine receptor

Abbreviation: RyR
The release channel for calcium ions that is found on the membranes of the sarcoplasmic reticulum of skeletal muscles.
See also: receptor
References in periodicals archive ?
The subsequent ROS sensitization of ryanodine receptors and sarcolemmal calcium influx channels increases myoplasmic calcium concentration and contraction leading to more stretch.
Screening of the entire ryanodine receptor type 1 coding region for sequence variants associated with malignant hyperthermia susceptibility in the north american population.
Phenotypes associated with malignant hyperthermia susceptibility in swine genotyped as homozygous or heterozygous for the ryanodine receptor mutation.
Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia.
Calcium regulatory proteins are mainly composed of L-type Ca[sup]2+ channels (LTCCs), ryanodine receptor 2 (RyR2), and Na[sup]+/Ca[sup]2+ exchanger (NCX).
Dominant mutations in the ryanodine receptor gene and recessive mutations in the calsequestrin-2 gene result in increased calcium current leak from the sarcoplasmic reticulum through the ryanodine receptor, resulting in intracellular calcium overload [17].
Effects of BPS on ryanodine receptor (RyR) and phospholamban (PLN) phosphorylation in female rat ventricular myocytes.
Anthranilic diamides: A new class of highly potent ryanodine receptor activators.
2000) for growth, ryanodine receptor (RYR1) (Fujii, 1991), and heart fatty acid binding protein (HFABP) (Gerbens et al.
MH is autosomally dominant inherited and over 200 mutations have been identified in the ryanodine receptor 1 (RYR1) gene, which is expressed in skeletal muscle (4,6).
For a long time, researchers have been studying the molecular defects that trigger arrhythmias and knew that the disorder is caused by mutations in two genes that encode calcium-handling proteins- the ryanodine receptor and calsequestrin.