The RYR1 gene encodes the skeletal muscle ryanodine
receptor, which serves as a calcium release channel of the sarcoplasmic reticulum as well as a bridging structure connecting the sarcoplasmic reticulum and transverse tubule.
Endoplasmic reticulum Ca2+ release channels, the ryanodine
receptors (a class of intracellular calcium channels), and the inositol 1, 4, 5-triphosphate receptors contribute to these processes, as well.
To validation of differentially expressed for differentially methylated genes between groups, we confirmed twelve differentially methylated genes in MeDIP-seq by real-time quantitative PCR, including TGFB3, ACSL1, ryanodine
receptor 1 (RYR1), ACOX2, peroxisome proliferator activated receptor-gamma2 (PPARG2), netrin 1 (NTN1), RIN2, microtubule associated protein RP/EB family member 1 (MAPRE1), ADAM metallopeptidase with thrombospondin type 1 motif 2 (ADAMTS2), myomesin 1 (MYOM1), ZDHHC13, and SH3 and PX domains 2B (SH3PXD2B).
This termiticide aims at the ryanodine
receptor of termites, instigating the discharge of stored calcium, subsequently causing muscle control loss, interruption in feeding, and eventually the death of the termite (Cordova et al, 2006) (Dupont, 2010).
Chlorantraniliprole and cyantraniliprole are novel anthranilic diamide insecticides that selectively bind to the ryanodine
receptors in muscle cells, resulting in the uncontrolled release of calcium stores (Lahm et al.
Benner, Rynaxypyr(tm): A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine
According to recent studies, people with virus induced RM are often carriers of mutations of RYR1 gene that creates defective ryanodine
receptor 1 on myocytes, thus creating susceptibility to malignant hyperthermia, which leads to RM.
Objective: This proposal is aiming at understanding the structural basis of the type 1 ryanodine
receptor (RyR1) regulation by post-translational modifications and by small molecules.
BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine
Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine
receptor expression in weanling rats.
Missense variants in the cardiac ryanodine
receptor encoding the ryanodine
receptor 2 (RYR2) gene are detected in approximately 50% of CPVT probands (17-19).
Chlorantraniliprole belongs to ryanodine
receptor modulator class of insecticides.