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An alkaloid obtained from Ryania speciosa (family Flacourtiaceae); has a disruptive effect on calcium storage in cardiac and skeletal muscle, where it produces sustained contractions; used as an insecticide.
References in periodicals archive ?
The RYR1 gene encodes the skeletal muscle ryanodine receptor, which serves as a calcium release channel of the sarcoplasmic reticulum as well as a bridging structure connecting the sarcoplasmic reticulum and transverse tubule.
Endoplasmic reticulum Ca2+ release channels, the ryanodine receptors (a class of intracellular calcium channels), and the inositol 1, 4, 5-triphosphate receptors contribute to these processes, as well.
To validation of differentially expressed for differentially methylated genes between groups, we confirmed twelve differentially methylated genes in MeDIP-seq by real-time quantitative PCR, including TGFB3, ACSL1, ryanodine receptor 1 (RYR1), ACOX2, peroxisome proliferator activated receptor-gamma2 (PPARG2), netrin 1 (NTN1), RIN2, microtubule associated protein RP/EB family member 1 (MAPRE1), ADAM metallopeptidase with thrombospondin type 1 motif 2 (ADAMTS2), myomesin 1 (MYOM1), ZDHHC13, and SH3 and PX domains 2B (SH3PXD2B).
This termiticide aims at the ryanodine receptor of termites, instigating the discharge of stored calcium, subsequently causing muscle control loss, interruption in feeding, and eventually the death of the termite (Cordova et al, 2006) (Dupont, 2010).
Chlorantraniliprole and cyantraniliprole are novel anthranilic diamide insecticides that selectively bind to the ryanodine receptors in muscle cells, resulting in the uncontrolled release of calcium stores (Lahm et al.
Benner, Rynaxypyr(tm): A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
According to recent studies, people with virus induced RM are often carriers of mutations of RYR1 gene that creates defective ryanodine receptor 1 on myocytes, thus creating susceptibility to malignant hyperthermia, which leads to RM.
Objective: This proposal is aiming at understanding the structural basis of the type 1 ryanodine receptor (RyR1) regulation by post-translational modifications and by small molecules.
BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine receptor-independent mechanisms.
Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats.
Missense variants in the cardiac ryanodine receptor encoding the ryanodine receptor 2 (RYR2) gene are detected in approximately 50% of CPVT probands (17-19).
Chlorantraniliprole belongs to ryanodine receptor modulator class of insecticides.