RUNX2

(redirected from runt-related transcription factor 2)

RUNX2

A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.

Molecular pathology
RUNX2 mutations cause cleidocranial dysplasia, a bone development disorder.
References in periodicals archive ?
Previous studies reported a connection between CCD and the haploinsufficiency of runt-related transcription factor 2 (RUNX2).
Nuclear localization of runt-related transcription factor 2 mutation
The research team reported that red-light absorbing carbon nitride (C3N4) sheets lead to remarkable proliferation and osteogenic differentiation by runt-related transcription factor 2 (Runx2) activation, a key transcription factor associated with osteoblast differentiation.
Runt-related transcription factor 2 (Runx2) has been identified as "a master gene" for OST differentiation at multiple stages.
Microgravity increased peroxisome proliferator-activated receptor a 2 but decreased Runt-related transcription factor 2 expression
4,5) The disease gene has been mapped to chromosome 6p21 within a region containing core-binding factor subunit alpha-1, a member of the runt family of transcription factors Runt-related transcription factor 2.