Tissue penetration properties of macrolide antibiotics--comparative tissue distribution of erythromycin-stearate, clarithromycin, roxithromycin
and azithromycin in rats.
This decrease was mainly due to the decrease in the sales of our two antibiotic products, Roxithromycin
Minimum inhibitory concentrations (MICs) were measured by using the microdilution method in triplicate for the following antimicrobial agents: erythromycin, clarithromycin, azithromycin, roxithromycin
, josamycin, tetracycline, doxycycline, levofloxacin, moxifloxacin, and ciprofloxacin.
The antimicrobial activity of A-56268 (TE-031) and roxithromycin
(RU 965) against Legionella using broth microdilution method.
coli isolates originally resistant to ciprofloxacin, cefoperazone, ceftazidime and roxithromycin
became sensitive to each of these antibiotics as a result of plasmid curing (Table III).
Tests of drinking water supplies in Columbus, Ohio, revealed the presence of the antibiotics azithromycin, roxithromycin
, tylosin, virginiamycin, as well as caffeine.
Drugs that triggered Torsades de Pointes Antibiotic agents Anti-arrhythmics Psychotropic agents Erythromycin (n=4) Sotalol (n=3) Amitryptiline (n=1) Roxithromycin
(n=2) Ibutilide (n=1) Haloperidol (n=1) Gatifloxacin (n=2) Quinidine (n=1) Fluoxetine (n=1) Clarithromycin (n=1) Amiodarone (n=1) Risperidone (n=1) Levofloxacin (n=1) Antibiotic agents Anti-histamines Erythromycin (n=4) Astemisol (n=2) Roxithromycin
(n=2) Terfanidine (n=1) Gatifloxacin (n=2) Clarithromycin (n=1) Levofloxacin (n=1)
The ANTIBIO trial (Antibiotic Therapy for Acute Myocardial Infarction) examined treatment with roxithromycin
(a macrolide antibiotic) versus placebo for 6 weeks in 872 patients presenting with acute MI.
For other PPCPs such as the macrolide antibiotic roxithromycin
significant differences were found, for instance between Germany (560 ng/l) and France (9ng/l).
Comparison of roxithromycin
with co-amoxiclav in patients with sinusitis.
pneumoniae strains were resistant to telithromycin, whereas the comparator drugs fared considerably worse: 36 strains were resistant to azithromycin, 37 to clarithromycin, 36 to erythromycin, 45 to roxithromycin
, and 20 to clindamycin.
pneumoniae-seropositive men suffering from peripheral arterial occlusive disease to receive either roxithromycin
(300 mg daily) or placebo for 1 month.