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(klok) a device for measuring time.
biological clock  the physiologic mechanism which governs the rhythmic occurrence of certain biochemical, physiologic, and behavioral phenomena in living organisms.


1. An instrument other than a watch for measuring or indicating time, especially a mechanical or electronic device having a numbered dial and moving hands or a digital display.
2. A biological clock.
v. clocked, clocking, clocks
To register or record with a mechanical device: clocked the winds at 60 miles per hour.

clock′er n.


A gene on chromosome 4q12 that encodes a ubiquitously expressed human homolog of the mouse clock gene, which forms a heterodimer with ARNTL and activates E-box element transcription of several circadian clock proteins (e.g., PER1 and PER2). CLOCK is highly expressed in the suprachiasmatic nucleus.

Molecular pathology
CLOCK-ARNTL double mutations in the PAS domains result in syngernistic desensitisation to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1, disrupting circadian rhythmicity.


A device for measuring time.

biological clock

1. An internal system in organisms that influences behavior in a rhythmic manner. Functions such as growth, feeding, secretion of hormones, the rate of drug action, the wake-sleep cycle, the menstrual cycle, and reproduction coincide with certain external events such as day and night, the tides, and the seasons. Biological clocks appear to be set by environmental conditions in some animals, but if these animals are isolated from their environment they continue to function according to the usual rhythm. A gradual change in environment does produce a gradual change in the timing of the biological clock. See: circadian; maladaptation to night work; zeitgeber
2. A colloquial term for the decrease in fertility that accompanies aging, particularly as women approach the age of 35.

Patient discussion about clock

Q. How do you wake up in the morning if your narcolepsy is so severe you can't hear the alarm clock, phone ring? biggest problem is sleep paralysis, can't wake up. Late for work, everything, life is suffering because of severity. Have tried ritalin, natural supplements, hypnosis therapy, Provigal, antidepressants, nothing seems to work. Employer thinks it's an excuse, friends are irritated, I'm at my wits end. Life is spent sleeping more than awake.

A. Narcolepsy cannot yet be cured. But EDS and cataplexy, the most disabling symptoms of the disorder, can be controlled in most patients with drug treatment. Often the treatment regimen is modified as symptoms change. For decades, doctors have used central nervous system stimulants-amphetamines such as methylphenidate, dextroamphetamine, methamphetamine, and pemoline-to alleviate EDS and reduce the incidence of sleep attacks. For most patients these medications are generally quite effective at reducing daytime drowsiness and improving levels of alertness. However, they are associated with a wide array of undesirable side effects so their use must be carefully monitored. Common side effects include irritability and nervousness, shakiness, disturbances in heart rhythm, stomach upset, nighttime sleep disruption, and anorexia. For full article: Hope this helps.

More discussions about clock
References in periodicals archive ?
Qatar's largest financial institution QNB said its Doha International Airport outlet and two e-branches in Dar Al Salam Mall and Al Khor Mall will operate round-the-clock during Eid al-Adha.
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CATASTROPHIC Elaine Kennedy-Lee with son James who needs round-the-clock care after being hit by a car
In a statement, the bank said, 'A local presence will allow the SNB to extend its coverage of markets in Asia, and will facilitate its round-the-clock operations on the foreign exchange market - for example, to enforce the minimum exchange rate.
Sami bin Mohamed Ba&'Dawood said the number of medical teams offering round-the-clock services to the needy in Jeddah affected districts amounted to 20 teams including 120 medical cadres.
The new number is already operational and is manned round-the-clock, which means people can speak to a waste management specialist any time and get advice on all aspects concerning the efficient management of waste.
In the midst of the bombings, rocket attacks and the fighting, nurses in Israel and Gaza are working round-the-clock shifts to treat the wounded and tend the dying.
Round-the-clock abbreviated pre-partum and extended post-partum counselling sessions were also offered.
In 2004 most GPs accepted an offer to opt out of providing round-the-clock care for their patients in return for an average pounds 6,000 drop in salary, with responsibility handed to primary care trusts.
A GP contract negotiated in 2004 allowed family doctors to opt out of round-the-clock service.
The E-Series all electric compression press is designed for round-the-clock performance in a laboratory or on the production floor.
reinforced its Medical Information Center (MIC) drug alert service by offering the round-the-clock service beginning on July 1.