round cell sarcoma

round cell sar·co·ma

obsolete term for an undifferentiated malignant neoplasm, believed to be of mesenchymal origin, composed chiefly of closely packed round cells.

round cell sarcoma

(1) A sarcoma (malignant tumour of mesenchymal origin) composed of round cells—e.g., epithelioid sarcoma, biphasic synovial sarcomas, some PEComas. The term is based on its histologic appearance and was used early in the diagnostic workup, before the results of immunohistochemical stains allow it to be slotted into a more specific category.
(2) An obsolete term for a lymphoma with round cells (lymphocytes) and a sarcomatoid stroma.
(3) Round cell tumour, see there. 
(4) Ewing sarcoma, see there.
References in periodicals archive ?
Chloe Bigmore, of Laleston, near Bridgend, died aged 14 in 2007 after contracting a rare cancer called desmoplastic round cell sarcoma.
Yondelis in adult and childhood small round cell sarcoma
3 mg/m2 is a promising anti-tumor agent for these childhood and adult sarcomas, this is of particular interest since Ewing's and desmoplastic small round cell sarcoma and rhabdomyosarcoma are aggressive tumors which occur more frequently in children than adults and account for nearly 10% of all childhood cancers.
Encouraging clinical data of Yondelis in combination with cisplatin and Phase II results in small round cell sarcomas (tumors that occur predominantly in children) were also reported.
High-grade round cell sarcoma, NOS 1/17 (6) 0/5 (0) Spindle cell sarcomas (n = 40) Monophasic synovial sarcoma .
There were 5 major morphologic patterns that emerged in which FISH was used including high-grade round cell sarcomas, spindle cell sarcomas, low-grade myxoid neoplasms, adipocytic neoplasms, and melanocytic neoplasms without an epidermal component.
FISH, not surprisingly, was most commonly used in the evaluation of high-grade round cell sarcomas (n = 67).
11,12) As with highgrade round cell sarcomas and spindle cell sarcomas, a number of these neoplasms, which did not contain a translocation identifiable by FISH, were classified as low-grade myxoid neoplasm, not otherwise specified.
3 mg/m squared is a promising anti-tumor agent for these childhood and adult sarcomas, this is of particular interest since Ewing's and desmoplastic small round cell sarcoma and rhabdomyosarcoma are aggressive tumors which occur more frequently in children than adults and account for nearly 10% of all childhood cancers.
Undifferentiated small round cell sarcomas with rare EWS gene fusions: identification of a novel EWS-SP3 fusion and of additional cases with the EWS-ETV1 and EWS-FEV fusions.
The histologic and immunohistochemical similarities, ranging from benign conditions such as osteomyelitis to monotonous round cell sarcomas, should be borne in mind when assessing these neoplasms to avoid misdiagnosis and inappropriate treatment.