Hence a diagnosis of malignant round cell sarcoma was made.
1 The malignant tumors in children include round cell sarcomas (Primitive Neu- roectodermal Tumors and Rhabdomyosarcomas), Hodgkin / Non-Hodgkin Lymphomas, Alveolar soft part sarcoma and fibrosarcomas.
Chloe Bigmore, of Laleston, near Bridgend, died aged 14 in 2007 after contracting a rare cancer called desmoplastic round cell sarcoma
High-grade round cell sarcoma, NOS 1/17 (6) 0/5 (0) Spindle cell sarcomas (n = 40) Monophasic synovial sarcoma .
There were 5 major morphologic patterns that emerged in which FISH was used including high-grade round cell sarcomas, spindle cell sarcomas, low-grade myxoid neoplasms, adipocytic neoplasms, and melanocytic neoplasms without an epidermal component.
FISH, not surprisingly, was most commonly used in the evaluation of high-grade round cell sarcomas (n = 67).
A small subset of round cell sarcomas clinically and histologically mimic Ewing sarcoma but fail to demonstrate any of the reported cytogenetic abnormalities described above.
High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas.
In the present series, round cell sarcomas
were more commonly found on lower extremities, which is comparable to that found by Roy et al.
Round cell sarcomas
beyond Ewing: emerging entities.
Undifferentiated small round cell sarcomas
with rare EWS gene fusions: identification of a novel EWS-SP3 fusion and of additional cases with the EWS-ETV1 and EWS-FEV fusions.
The histologic and immunohistochemical similarities, ranging from benign conditions such as osteomyelitis to monotonous round cell sarcomas
, should be borne in mind when assessing these neoplasms to avoid misdiagnosis and inappropriate treatment.