round cell

round cell

Haematology
A generic term for a relatively small (10–20 µm) leukocyte with usually a single round-to-oval nucleus.

Examples
Lymphocytes, monocytes, plasma cells, occasionally epithelioid histiocytes.
 
Pathology
A term of art for any round cell of unknown lineage, the nature of which can be often be determined with immunohistochemistry.
References in periodicals archive ?
The test results can be read in the photometer included with the kit or any spectrophotometer that accepts a 13 mm round cell, enabling operators to use existing laboratory equipment.
Cell Test Port offers direct insertion of round cell tests without opening any lids
Time to secondary resistance (TTSR) after rechallenge with trabectedin (T) in myxoid round cell liposarcoma (MRCLPS) patients.
Histopathologic examination of the mass supported a diagnosis of malignant round cell neoplasia.
These changes include round cell shrinkage, significant change in the shape of the nucleus, cytoskeletal damage when tubulin was degraded, and reduction of mitochondrial transmembrane potential.
On her return, scans revealed a desmosplastic small blue round cell tumour - an aggressive and rare soft cell sarcoma that has a five-year survival rate of just 15%.
Chapters address the dominant cytology of the tumor cells (spindle cell tumors, epithelioid tumors, round cell tumors, pleomorphic sarcomas, biphasic tumors, and tumors with mixed patterns), the quality of the extracellular matrix (tumors with myxoid stroma), and other distinguishing features (giant cell-rich tumors and soft tissue tumors with prominent inflammatory cells).
Cytokeratin was positive in surface cells in all 5 cases in which this was available (100%) (Figure 1, C); 3 cases had no round cell staining for cytokeratin and 2 showed weak patchy staining (40%).
Considering all these features, a diagnosis of a small round cell neoplasm, probably embryonal rhabdomyosarcoma was considered and immunohistochemistry was performed.
However, kidneys showed minimal patchy round cell infiltration of interstitial cells (NIV unpublished data).
Chloe Bigmore, of Laleston, near Bridgend, died aged 14 in 2007 after contracting a rare cancer called desmoplastic round cell sarcoma.