ristocetin


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ris·to·ce·tin

(ris'tō-sē'tin),
An antibiotic produced by the fermentation of Amycolatopsis orientalis subsp. lurida, comprising two substances; ristocetin A and ristocetin B; although no longer used, it causes platelet agglutination and blood coagulation and was used to assay those functions.
Synonym(s): ristomycin

ristocetin

(rĭs″tō-sē′tĭn)
An antibiotic obtained from cultures of Nocardia lurida.

ristocetin

an antibiotic produced by cultures of the actinomycete Nocardia lurida. Used also in the assessment of platelet function.

ristocetin cofactor
inolved in platelet aggregation. Called also von Willebrand factor.
References in periodicals archive ?
Criteria for diagnosis of Glanzmann's thrombasthenia (GT) were normal PT, aPTT, platelet count, and morphology; no curve with ADP, epinephrine, or collagen; and normal curve with ristocetin in platelet aggregation by lumiaggregometry.
GT is a rare autosomal recessive disorder characterized by mucocutaneous bleeding and absent or severely reduced platelet aggregation in response to the physiological agonists ADP, epinephrine, and collagen, but relatively normal aggregation in response to ristocetin (7).
In general, most patients with vWD do not require prophylactic replacement therapy, especially for Type 1 disease or if the ristocetin cofactor levels are more than 50% of normal.
In the assay plasma vWF binds to the platelet gp1b receptor on lyophilised reagent platelets and agglutinates the platelets in the presence of ristocetin.
6mM fc), normal aggregation with a secondary wave to the 'weak' agonists ADP and epinephrine (respectively @ 5uM and 10uM fc), normal aggregation with the 'strong' agonist collagen (@ minimum of lug/ml fc) and normal aggregation to ristocetin (@ between 1.
Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin.
A STUDY ON CHIRAL RESOLUTION USING MIXTURES OF THE CHIRAL SELECTORS VANCOMYCIN AND RISTOCETIN A
VWF:Ag, ristocetin cofactor activity (VWF:RCo), collagen binding with type III VWF:CB, and multimer distribution were performed on all samples as previously described (11).
Results: Based on the von Willebrand factor antigen (vWF:Ag) and ristocetin cofactor activity (vWF:RCo) levels and bleeding symptoms, vWD type-1 was diagnosed in 14 individuals (4 males, 10 females; prevalence: 1.
PRODUCT INTRODUCTIONS/INNOVATIONS II-35BD Diagnostics Unveils BD Microtainer MAP Microtube II-35iCyt Launches New Flow Cytometry Products II-35Applied Biosystems Introduces AttuneTM Acoustic FocusingCytometer II-35Bio/Data Unveils a Pioneering Ristocetin CoFactor Assay, vWSelect (TM) II-35BD Biosciences Rolls Out BD Kaleidoscope Reagent and DyeExpansion Program II-36
Testing platelet response to the agonists ADP, Collagen, Epinephrine and Ristocetin showed an increased response to low concentration Ristocetin (Figure 1a) which is consistent with type 2B vWD (1).
For more than two decades, the ristocetin cofactor (RCo) assay, which measures the vWF-mediated agglutination of platelets in the presence of the antibiotic ristocetin, has been the most common method for measuring the functional activity of vWF.