rippling muscle disease


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A rare, usually autosomal dominant [MIM 606072],occasionally sporadic disorder of adolescent onset, that occurs when local muscle compression evokes myo-oedema, followed by longitudinal contraction, moving transversely across the muscle in a 10-20 muscle fascicle wave, fancifully likened to ‘plucking a chromatic scale on a harp’; while resembling myotonia, rippling muscle disease is electrically silent and clinically benign

rippling muscle disease

A usually AD, occasionally sporadic disorder of adolescent onset, that occurs when local muscle compression evokes myoedema, followed by longitudinal contraction, moving transversely across the muscle in a 10-20 muscle fascicle wave, fancifully likened to 'plucking a chromatic scale on a harp'; while resembling myotonia, RMD is electrically silent and clinically benign. See Myotonia.

rippling muscle disease

A rare autosomal dominant muscle disease whose symptoms include spontaneous muscle contraction when muscles are stimulated by stretching, percussion, or squeezing. Affected patients are usually recognized during childhood. They may demonstrate weakness of facial muscles, frequent falls, or difficulty walking on their heels or toes as a result of calf muscle weakness.