rimantadine hydrochloride


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rimantadine hydrochloride

Pharmacologic class: Miscellaneous and anticholinergic-like agent

Therapeutic class: Antiviral

Pregnancy risk category C

Action

Prevents nucleic acid uncoating during viral cell replication, preventing penetration in host. Also causes dopamine release from neurons.

Availability

Syrup: 50 mg/5 ml

Tablets: 100 mg

Indications and dosages

Treatment of influenza type A

Adults: 100 mg P.O. b.i.d.

Prophylaxis of influenza type A

Adults and children older than age 10: 100 mg P.O. b.i.d.

Children younger than age 10: 5 mg/kg P.O. daily. Maximum dosage is 150 mg daily.

Dosage adjustment

• Renal or hepatic disease
• Seizure disorders
• Elderly patients

Off-label uses

• Parkinson's disease

Contraindications

• Hypersensitivity to drug or amantadine

Precautions

Use cautiously in:
• history of seizures or renal or hepatic disease
• pregnant or breastfeeding patients
• children younger than age 1.

Administration

• Give several hours before bedtime.
• Start therapy within 48 hours of symptom onset and continue for at least 1 week.

Adverse reactions

CNS: headache, dizziness, fatigue, depression, insomnia, poor concentration, asthenia, nervousness

CV: hypotension

EENT: tinnitus

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, dry mouth, anorexia

Respiratory: dyspnea

Skin: rash

Interactions

Drug-drug.Acetaminophen, aspirin: decreased rimantadine peak blood level

Cimetidine: increased rimantadine blood level

Patient monitoring

• Assess patient's flu symptoms. Notify prescriber if symptoms don't improve within 2 to 3 days.
• Monitor vital signs; watch for hypotension.
• Closely monitor nutritional status and hydration.

Patient teaching

• Advise patient to take several hours before bedtime.
• If patient's taking syrup, tell him to use specially marked oral syringe or measuring device to ensure accurate dose.
• Instruct patient to contact prescriber if symptoms don't improve within 2 to 3 days.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, motor function, and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

rimantadine hydrochloride

(rĕ-măn-tĕ-dēn)
An antiviral drug given orally to treat influenza A.
References in periodicals archive ?
The significant year-over-year increase came on additional sales of Fludrocortisone Acetate Tablets, introduced at the end of the first quarter of 2002, Minocycline Hydrochloride Capsules launched in the third quarter of 2002, Rimantadine Hydrochloride Tablets launched in the fourth quarter of 2002, higher Lipram sales, and lower product returns.
The significant year-over-year increase came on the ramp up of sales of Fludrocortisone Acetate Tablets, introduced at the end of the first quarter of 2002, Minocycline Hydrochloride Capsules launched in the third quarter of 2002, Rimantadine Hydrochloride Tablets launched in the fourth quarter of 2002, Terbutaline Sulfate Tablets introduced since July 2001, higher Lipram sales, and lower product returns.
Clinical trials have documented that amantadine hydrochloride [4,5,6,8,13] and its analog rimantadine hydrochloride [3,5,10,13,12] are effective drugs for the prophylaxis and treatment of influenza A virus infection.