Treatment of influenza: the therapeutic efficacy of rimantadine
HCI in naturally occurring influenza A2 outbreak.
Dr Griffin said: "We 'borrowed' rimantadine
to test its effects because p7 behaves similarly to a protein found in the flu virus.
13) However, in 2005-2006, CDC documented that 91 percent of influenza A (H3N2) viruses tested in 23 states had a mutation that conferred resistance to amantadine and rimantadine
and recommended that these drugs not be used during the 2005-2006 influenza season.
However, four drugs have been approved to treat people who get the flu: amamadine (Symmetrel), rimantadine
(Flumadine), zanamivir (Relenza), and oseltamivir (Tamiflu).
Amantadine and rimantadine
were both recommended for treatment and prophylaxis of influenza A, but more recent information indicates viral resistance to these drugs.
This drug and its congener, rimantadine
(not available in South Africa), specifically inhibit the replication of influenza A viruses (they are ineffective against influenza B viruses) in low concentrations of about 0.
33,36) Amantadine (37) and rimantadine
, (38,39) both older anti-influenza drugs, are both efficacious against influenza A, but they tend to have more side effects, and resistance to these drugs by influenza strain is increasing significantly.
FDA said beginning this summer, it is proposing to ban veterinarians from prescribing off-label, nonhuman uses of Tamiflu, amantadine and rimantadine
Most H5N1 viruses that have caused human illness and death appear to be resistant to amantadine and rimantadine
, two antiviral medications commonly used for treatment of patients with influenza.
If taken early, the antiviral agents amantadine and rimantadine
are effective in reducing the severity of influenza A, while zanamivir and oseltamivir are effective in reducing the severity of both influenza A and B.
Until then, four different antiviral drugs (amantadine, rimantadine
, oseltamivir, and zanamivir) are approved by the U.
The World Health Organisation says this year's strain is resistant to cheaper anti- viral drugs amantadine and rimantadine