ribozyme


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ri·bo·zyme

(rī'bō-zīm),
A nonprotein RNA biocatalyst; several cleave precursors of tRNA to yield functional tRNAs; others act on rRNA; plays a key role in intron splicing events.
Synonym(s): organic catalyst (1) , RNA enzyme
[ribonucleic acid + -zyme]

ribozyme

(rī′bə-zīm′)
n.
An RNA molecule that acts as a catalyst, especially for the cleavage of RNA strands at specific sites.

ribozyme

One of a unique class of RNA molecules that can act as cleaving enzymes in addition to storing genetic information. This is a notable exception to the general rule that all enzymes are proteins. Ribozymes form complementary base pairs in the normal manner but can cleave segments of nascent RNA during the splicing process of the formation of mature RNA transcripts of DNA. Ribozymes can be used in various ways as treatment modalities.

ribozyme

an RNA molecule with catalytic activity. Ribozymes include (a) molecules involved in processing RNA precursor molecules by cleaving PHOSPHODIESTER BONDS, for example in self-SPLICING of some precursor rRNA INTRONS; and (b) molecules catalysing key cellular reactions, for example rRNA of the large ribosomal subunit (see RIBOSOME), which is closely involved with the peptidyl transferase activity that catalyses PEPTIDE BOND formation in TRANSLATION. Ribozymes are found in EUCARYOTES, PROKARYOTES, VIRUSES and VIROIDS.

ribozyme

enzyme whose catalytic function is carried out by an RNA subunit; of the four known classes, three carry out self processing reactions while the fourth, ribonuclease P (RNase P), is a true catalyst; discovered in the context of RNA splicing.
References in periodicals archive ?
The researchers are now working to put the right-handed ribozyme (and by implication its left-handed partner) through more selection rounds, so that it can mediate the full replication of RNA, with essentially no sequence-dependence.
To determine the ability of the hammerhead ribozyme Vif5113 to inhibit vif expression, a transient inhibition assay was employed.
To determine whether shorter sequences are advantageous in selection experiments, we have used size heterogeneous RNA pools to isolate a series of thioester synthase ribozymes.
This has led some researchers to suggest that the aminoglycoside antibiotic-binding sites on the ribosome are related to the aminoglycoside antibiotic-binding sites on ribozymes, and thus that ribozymes and ribosomal RNA are somehow historically related (13).
We found that magnesium ions bind to a special location on the ribozyme to keep the mouth open," said Smith.
Joyce's specialty is the creation of ribozyme systems that replicate and even evolve somewhat--on the verge of life, but not quite there.
Each of these ribozymes and a corresponding non-catalytic control ribozyme was cloned into the shuttle vector, pPCR-Script.
I see Ribozyme putting Colorado on the map, in terms of biotech.
The most prevalent ribozyme (40% of the final, doubly-selected pool) has been characterized.
Li has experience in gene silencing related technologies, including RNAi and ribozyme based platforms.
Previously, Dr Cowens worked in senior medical positions at Genomic Health, held senior product development positions at Chiron (now Novartis Vaccines & Diagnostics) and Ribozyme Pharmaceuticals as well as worked as an oncology consultant for IDEC Pharmaceuticals, Scios and Ligand Pharmaceuticals.
The purpose of this experiment was to design and synthesize a catalytic hammerhead ribozyme targeted to the GUA target site located at nucleotide 8618 NL43 HIV Rev gene.