ribozyme


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ri·bo·zyme

(rī'bō-zīm),
A nonprotein RNA biocatalyst; several cleave precursors of tRNA to yield functional tRNAs; others act on rRNA; plays a key role in intron splicing events.
Synonym(s): organic catalyst (1) , RNA enzyme
[ribonucleic acid + -zyme]

ribozyme

(rī′bə-zīm′)
n.
An RNA molecule that acts as a catalyst, especially for the cleavage of RNA strands at specific sites.

ribozyme

One of a unique class of RNA molecules that can act as cleaving enzymes in addition to storing genetic information. This is a notable exception to the general rule that all enzymes are proteins. Ribozymes form complementary base pairs in the normal manner but can cleave segments of nascent RNA during the splicing process of the formation of mature RNA transcripts of DNA. Ribozymes can be used in various ways as treatment modalities.

ribozyme

an RNA molecule with catalytic activity. Ribozymes include (a) molecules involved in processing RNA precursor molecules by cleaving PHOSPHODIESTER BONDS, for example in self-SPLICING of some precursor rRNA INTRONS; and (b) molecules catalysing key cellular reactions, for example rRNA of the large ribosomal subunit (see RIBOSOME), which is closely involved with the peptidyl transferase activity that catalyses PEPTIDE BOND formation in TRANSLATION. Ribozymes are found in EUCARYOTES, PROKARYOTES, VIRUSES and VIROIDS.

ribozyme

enzyme whose catalytic function is carried out by an RNA subunit; of the four known classes, three carry out self processing reactions while the fourth, ribonuclease P (RNase P), is a true catalyst; discovered in the context of RNA splicing.
References in periodicals archive ?
The researchers are now working to put the right-handed ribozyme (and by implication its left-handed partner) through more selection rounds, so that it can mediate the full replication of RNA, with essentially no sequence-dependence.
To determine the ability of the hammerhead ribozyme Vif5113 to inhibit vif expression, a transient inhibition assay was employed.
If the lengths of the binding arms are too short, the rate of dissociation of the target from the ribozyme will exceed the rate of cleavage, resulting in poor turnover.
Certain types of RNA called ribozymes are capable of both storing genetic information and catalyzing chemical reactions - two necessary features in the formation of life.
Correct ribozyme insertion into the resulting plasmids, pSRNG5910 and pSRNG5910[DELTA], was verified by sequencing.
Ribozyme is the acknowledged leader in ribozyme therapeutic development.
Contrary to Gene Shears' assertion, Ribozyme maintains the claims of this patent broadly cover ribozymes with endoribonuclease activity.
Couture of Ribozyme Pharmaceuticals in Boulder, Colo.
If a ribozyme specific to HIV RNA were present inside the cells that the virus infects, then it could constitute a first-line defense against the invasion.
The design and cloning of an anti-tat hammerhead ribozyme targeted to one of these sites, a GUC sequence, located at nucleotide 5877 of the HIV-1 genomic clone NL43 is described.
Corporate Communications, Ribozyme Pharmaceuticals, Inc.
Canberra, Australia) announced that the European Patent Office has maintained without amendment European Patent 0360257 after an opposition filed by Ribozyme Pharmaceuticals, Inc.