It catalyses the conversion of succinylaminoimidazole carboxamide ribotide
(SAICAR) to aminoimidazole carboxamide ribotide
(AICAR), as well as, the formation of adenosine monophosphate (AMP) from adenylosuccinate in the purine nucleotide cycle (Kmoch et al.
Inhibition of 5-aminoimidazole-4-carboxamide ribotide
transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide
This concerns the conversion of SAICA-ribotide
into aminoimidazole carboxamide ribotide
and of adenylosuccinate into AMP (Fig.