rheumatoid spondylitis


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Related to rheumatoid spondylitis: Marie-Strümpell disease, Bamboo spine

spondylitis

 [spon″dĭ-li´tis]
inflammation of the vertebrae, usually a serious and chronic disorder. It may be associated with tuberculosis of the bones, in which case it is called pott's disease. The vertebrae become eroded and collapse, causing kyphosis. Spondylitis may also be associated with other infectious diseases, such as brucellosis, in which the intervertebral disks and the vertebrae are affected and sometimes destroyed; this is one cause of ankylosing spondylitis, a particularly serious variety.
ankylosing spondylitis (Bekhterev's spondylitis) a form of rheumatoid arthritis that affects the spine, characterized by inflammation of the facet joints and inflammatory changes of the stabilizing ligaments of the spine (enthesopathy). It affects males almost exclusively. There is stiffening of spinal joints and ligaments, so that movement becomes increasingly painful and difficult. When it runs its full course, it results in bony ankylosis of the vertebral joints, which may extend to the ribs and limit the flexibility of the rib cage, so that breathing is impaired. Called also Marie-Strümpell disease or spondylitis and rheumatoid spondylitis.
Typical posture of patient with ankylosing spondylitis. From Copstead and Banasik, 2000.
Kümmell's spondylitis Kümmell's disease.
Marie-Strümpell spondylitis ankylosing spondylitis.
post-traumatic spondylitis Kümmell's disease.
rheumatoid spondylitis ankylosing spondylitis.

an·ky·los·ing spon·dy·li·tis

[MIM*106300]
arthritis of the spine, resembling rheumatoid arthritis, which may progress to bony ankylosis with ossification of the anterior and posterior longitudinal ligaments; the disease is more common in males, often with the rheumatoid factor absent and the HLA antigen present. There is a striking association with the B27 tissue type and the strong familial aggregation suggests an important genetic factor, perhaps inherited as an autosomal dominant [MIM*106300]; the mechanism, however, remains obscure.

rheumatoid spondylitis

an·ky·los·ing spon·dy·li·tis

(ang'ki-lōs-ing spon'di-lī'tis)
Arthritis of the spine, resembling rheumatoid arthritis, which may progress to bony ankylosis with lipping of vertebral margins; the disease is more common in the male, often with the rheumatoid factor absent and the HLA antigen present. There is a striking association with the B27 tissue type and the strong familial aggregation suggests an important genetic factor.
Synonym(s): rheumatoid spondylitis.

rheumatoid spondylitis

See ANKYLOSING SPONDYLITIS.

Patient discussion about rheumatoid spondylitis

Q. Is ankylosing spondylitis genetically inherited?

A. It is known today that ankylosing spondylitis (spondyloarthritis) has a very strong genetic connection. It is not a disease inhertited by a single gene that is dominant, but certainly there is genetic predisposition in families (and a more detailed information- about 90% of the patients express the HLA-B27 genotype).

More discussions about rheumatoid spondylitis