revertant


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re·ver·tant

(rē-ver'tănt),
In microbial genetics, a mutant that has reverted to its former genotype (true reversion) or to the original phenotype by means of a suppressor mutation.
[L. revertans, pres.p. of reverto, to turn back]

revertant

(rĭ-vûr′tnt)
adj.
Having reverted to the normal phenotype, usually by a second mutation: a revertant mutant; revertant cells.
n.
A revertant organism, cell, or strain.

re·ver·tant

(rē-vĕr'tănt)
microbial genetics A mutant that has reverted to its former genotype (true reversion) or to the original phenotype by means of a suppressor mutation.
[L. reverto, to turn back]

revertant

see REVERSION.

Patient discussion about revertant

Q. Could it revert back to my mom? If yes, how to deal with it? my mom’s lump is removed, chemotherapy is just over and she is getting well. My mom is a tea and coffee lover. But with doctors advice she did cut down on tea/coffee say once in a week. Could it revert back to my mom? If yes, how to deal with it?

A. Tea and coffee do not have any impact on the breast cancer recurrence. Caffeine in the coffee needs to be monitored as it increases some symptoms for breast lumps which are not cancerous but can increase the risk for cancer. It doesn’t show any link in cancer recurrence. Tea has nothing to do with cancer recurrence rather it is being proved having green tea helps in reduction of the tumor. Your mom can have green tea, if she feels unsafe to have coffee or normal tea.

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A mutagenic effect (increase in revertant colony numbers as compared to control counts) was not observed for any of the valerian extracts tested up to the concentration of 5000 [micro]g/plate in any of the 5 test strains in two independent experiments with and without metabolic activation (plate incorporation and pre-incubation test, respectively), even if common regulatory thresholds of 2 (for strains TA 98, TA 100, TA 1535 and TA 1537) or 1.
Significantly increasec values compared to NR point to a potential enhancement of revertant rates, reduced values to cytotoxicity.
Juices from ten citrus varieties reduced significantly the number of revertant colonies induced by N-nitro-o-phenylenediamine (NPD) in TA 97a and sodium azide in TA 100 strains of Salmonella typhimurium (Bala & Grover, 1989).
Significant increases in the number of revertant colonies were induced by the known mutagens and carcinogens sodium azide, 2-nitrofluorene, 2-aminoanthracene when tested under the same conditions (Meester and Leonard, 1988).
2]) indicated a count of more than twice the revertant colonies of TA 102 as the negative control.
Pseudogene rp028 was inactivated in a virulent E strain but not in its virulent revertant Evir strain (9).
E strain and its revertant Evir strain differed by a single nucleotide insertion in E strain at position 732 in rp028, which we reported previously (9).
Concentrations needed for 50% inhibition of mutagen-induced revertant formation was found to be 5 mg/plate.
The plates were incubated for 48 h at 37[degrees]C and the revertant colonies were counted using a colony counter.
25-100 [micro]g/plate was also checked for possible toxic or mutagenic effects in both TA98 and TA100 strains and no change in spontaneous revertant count indicated absence of any mutagenic/toxic effects of DBM in the tested dose range (see footnote of Tables 1-3 for revertant counts).
Histidine revertant colonies were scored after 48 hrs of incubation.
The revertant colonies were counted, and the toxic effect was determined by viewing the background lawn under a stereo microscope.