reversible injury

reversible injury

Pathology Ischemic changes–eg, of the myocardium, that can be reversed with timely return of normal circulation to the tissue of interest
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Initially, prolonged cardiac troponin release was not observed in patients with pulmonary embolism, a finding that led to the idea that pulmonary embolism was a pathology in which release came only from the releasable pool and therefore could be indicative of reversible injury and not cell death (5).
For preload increases, the cells die because of apoptosis; therefore, that does not appear to be a circumstance in which reversible injury occurs.
This controversy has continued unabated with the emergence of several other lines of clinical evidence indicating that reversible injury can be the mechanism of cardiac troponin release.
First, if answering this question is problematic with cardiac troponins, it is very likely also problematic with all of the biomarkers, including CK-MB and LDH, although cardiac troponin is a smaller protein and thus might be more prone to release with reversible injury.
But it may also be speculated that late reabsorption of prilocain if it was injected within the myelin sheath or immediate healing of a small reversible injury of the neuronal fibers might have been the reasons.
Amiodarone, while a highly effective antidysrhythmic, has the potential to cause severe pulmonary toxicity, ranging from mild, reversible injury to pulmonary fibrosis.
Increased plasma CK activity in the setting of chest pain and electrocardiographic (EKG) changes has been interpreted to reflect irreversible myocardial injury (necrosis) rather than reversible injury, e.
In contrast, plasma concentrations of neither mitochondrial nor cytosolic CK were increased in animals with 15 min or less of coronary occlusion despite extensive EKG and morphological evidence of ischemic reversible injury.
Furthermore, this conclusion is strengthened by measures taken to induce severe and extensive myocardial ischemia to optimize conditions to detect even a very small release of CK into the plasma, which may occur with even minimal reversible injury.

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