reverse transcriptase


Also found in: Dictionary, Thesaurus, Financial, Acronyms, Encyclopedia, Wikipedia.
Related to reverse transcriptase: reverse transcription, Reverse transcriptase inhibitors

reverse transcriptase

 [re-vers´ tran-skrip´tās]
an enzyme of RNA viruses that catalyzes the transcription of RNA to DNA, which is then incorporated into the genome of the host cell. This is the reverse of the usual mechanism for replication of genetic information; in the presence of this enzyme it is the RNA that serves as the template for DNA copies. It is one mechanism by which reproduction of cancer cells is facilitated. Called also RNA-directed DNA polymerase.

re·verse tran·scrip·tase

RNA-dependent DNA polymerase, present in virions of RNA tumor viruses (retroviruses).

reverse transcriptase

/re·verse tran·scrip·tase/ (re-vers´ tran-skrip´tās) an enzyme that catalyzes the template-directed, step-by-step addition of deoxyribonucleotides to the end of a DNA or RNA primer or growing DNA chain, using a single-stranded RNA template; it occurs in retroviruses and the DNA formed is an intermediate in the formation of progeny RNA.

reverse transcriptase

n.
A polymerase that catalyzes the formation of DNA on an RNA template, found in the retroviruses and in certain other viruses, such as hepatitis B virus.

reverse transcriptase (RT)

[revers′tran-skrip′tās]
an enzyme of RNA viruses that catalyzes the transcription of RNA to DNA, which is then incorporated into the genome of the host cell. This is the reverse of the usual mechanism for replication of genetic information; in the presence of this enzyme, it is the RNA that serves as the template for DNA copies. It is one mechanism by which reproduction of cancer cells is facilitated. Also called RNA-dependent DNA polymerase. See also retrovirus.

re·verse trans·crip·tase

(RT) (rē-vĕrs' tran-skrip'tās)
RNA-dependent DNA polymerase, present in virions of RNA tumor viruses.

reverse transcriptase

An enzyme that allows certain viruses, notable HIV, to synthesize double strand DNA from a single strand of RNA so that it can be incorporated into the genome of the host cell. Such viruses are called retroviruses.

reverse transcriptase

an RNA-dependent DNA polymerase that catalyses the synthesis of DNA from deoxyribonucleoside-5′-triphosphate, using RNA as a template.

re·verse trans·crip·tase

(rĕ-vĕrs' tran-skrip'tās)
RNA-dependent DNA polymerase, present in virions of RNA tumor viruses.

reverse transcriptase (transkrip´-tās),

n an enzyme within a retrovirus that converts its ribonucleic acid into deoxyribonucleic acid (DNA), which then penetrates the cell nucleus and joins the host's DNA.

reverse transcriptase

see reverse transcriptase.
References in periodicals archive ?
Reverse transcriptase polymerase chain reaction (RT-PCR)
Potential risks and uncertainties include, but are not limited to, a) Invitrogen's ability to successfully defend its patents on reverse transcriptase and other products in the future, b) the competitiveness of Invitrogen's reverse transcriptase and other products and the demand for them as determined by the direction of scientific research, in addition to other risks and uncertainties detailed from time to time in the Company's Securities and Exchange Commission filings.
Luzuriaga's team wanted to try a three-pronged attack with AZT and two other drugs that also block reverse transcriptase.
NNRTIs (non-nucleoside reverse transcriptase inhibitor) target the same reverse transcriptase enzyme, but do not provide false building blocks.
These enzymes are targets for therapy, and to date researchers have identified and successfully tested inhibitors of two of HIV's enzymes, namely reverse transcriptase and protease.
The origin of reverse transcriptase is murky and controversial," Goff says.
VIRAMUNE(R) is a member of a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs).
The product contains 600 mg of efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI), 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate, both nucleoside reverse transcriptase inhibitors (NRTIs).
This is a very active antiretroviral of the NNRTI class (non-nucleoside reverse transcriptase inhibitor -- the same class as efavirenz, nevirapine, and delavirdine, the three NNRTI drugs currently approved in the U.
However, these 25 patients, all of whom were naive to non-nucleoside reverse transcriptase inhibitors (NNRTIs), were given efavirenz (Sustiva), a potent NNRTI, in addition to Kaletra and nucleoside reverse transcriptase inhibitors (NRTIs).
The virus manufactures DNA from this RNA using an enzyme called reverse transcriptase.
A nucleoside analogue, 1592U89 acts by inhibiting the HIV reverse transcriptase, an enzyme which is essential to the replication of the virus.

Full browser ?