reverse transcriptase


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Related to reverse transcriptase: reverse transcription, Reverse transcriptase inhibitors

reverse transcriptase

 [re-vers´ tran-skrip´tās]
an enzyme of RNA viruses that catalyzes the transcription of RNA to DNA, which is then incorporated into the genome of the host cell. This is the reverse of the usual mechanism for replication of genetic information; in the presence of this enzyme it is the RNA that serves as the template for DNA copies. It is one mechanism by which reproduction of cancer cells is facilitated. Called also RNA-directed DNA polymerase.

re·verse tran·scrip·tase

RNA-dependent DNA polymerase, present in virions of RNA tumor viruses (retroviruses).

reverse transcriptase

/re·verse tran·scrip·tase/ (re-vers´ tran-skrip´tās) an enzyme that catalyzes the template-directed, step-by-step addition of deoxyribonucleotides to the end of a DNA or RNA primer or growing DNA chain, using a single-stranded RNA template; it occurs in retroviruses and the DNA formed is an intermediate in the formation of progeny RNA.

reverse transcriptase

n.
A polymerase that catalyzes the formation of DNA on an RNA template, found in the retroviruses and in certain other viruses, such as hepatitis B virus.

reverse transcriptase (RT)

[revers′tran-skrip′tās]
an enzyme of RNA viruses that catalyzes the transcription of RNA to DNA, which is then incorporated into the genome of the host cell. This is the reverse of the usual mechanism for replication of genetic information; in the presence of this enzyme, it is the RNA that serves as the template for DNA copies. It is one mechanism by which reproduction of cancer cells is facilitated. Also called RNA-dependent DNA polymerase. See also retrovirus.

re·verse trans·crip·tase

(RT) (rē-vĕrs' tran-skrip'tās)
RNA-dependent DNA polymerase, present in virions of RNA tumor viruses.

reverse transcriptase

An enzyme that allows certain viruses, notable HIV, to synthesize double strand DNA from a single strand of RNA so that it can be incorporated into the genome of the host cell. Such viruses are called retroviruses.

reverse transcriptase

an RNA-dependent DNA polymerase that catalyses the synthesis of DNA from deoxyribonucleoside-5′-triphosphate, using RNA as a template.

re·verse trans·crip·tase

(rĕ-vĕrs' tran-skrip'tās)
RNA-dependent DNA polymerase, present in virions of RNA tumor viruses.

reverse transcriptase (transkrip´-tās),

n an enzyme within a retrovirus that converts its ribonucleic acid into deoxyribonucleic acid (DNA), which then penetrates the cell nucleus and joins the host's DNA.

reverse transcriptase

see reverse transcriptase.
References in periodicals archive ?
The influence of the three descriptors on the inhibitory activity of HIV-1 reverse transcriptase can be interpreted chemically.
Reverse transcriptase polymerase chain reaction (RT-PCR)
Four-hundred and forty-seven HIV-1 infected patients have received combination therapy with Emtriva and Viread with either a non-nucleoside reverse transcriptase inhibitor (Study 934) or protease inhibitor for 48 weeks in clinical studies.
Merck also intends to commence with a Phase II study of MK-1439, an investigational next generation non-nucleoside reverse transcriptase inhibitor.
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild type and drug-resistant HIV variants.
Pol: An HIV gene that encodes the viral enzymes protease, reverse transcriptase, and integrase.
Luzuriaga's team wanted to try a three-pronged attack with AZT and two other drugs that also block reverse transcriptase.
STOCKHOLM, Sweden -- Medivir AB (STO:MVIRB), Sweden, and Guangdong Lantai Viewland Pharmaceutical, China, announced today the signing of a licensing agreement on MIV-160 (MV026048), a non-nucleoside HIV reverse transcriptase inhibitor (NNRTI) in late pre-clinical development.
Additionally, the company announced plans to initiate a Phase II study for a proprietary investigational next generation non-nucleoside reverse transcriptase inhibitor, MK-1439.
NRTIs (nucleoside reverse transcriptase inhibitor) target reverse transcriptase (an enzyme of HIV), by providing false building blocks that the enzyme puts into new copies of the virus it is building.
But many clinicians are still unsure of whether to use abacavir as part of a first treatment regimen or to save it for later, or whether to combine it with a protease inhibitor or a non-nucleoside reverse transcriptase inhibitor.
The DNA polymerase is a reverse transcriptase, the kind of enzyme that HIV and other retroviruses use to copy their RNA-encoded genetic information into an infected cell's DNA (SN: 5/9/92, p.

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