retinol binding protein


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retinol binding protein (RBP)

A single-chain polypeptide glycoprotein secreted in fat cells and the liver. It is a member of the alpha globulin family of plasma proteins. It binds and solubilizes retinol and protects it from oxidation. RBP 4 is elevated before the development of frank diabetes and appears to indicate insulin resistance.
References in periodicals archive ?
Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation.
Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects.
Posterboard Number: B807 , Program Number: 3903 ARVO poster presentations featuring ST-602 (fenretinide): Reduction of Serum Retinol Binding Protein Arrests the Accumulation of Toxic Retinal Fluorophores: A Nonpharmacological Approach Session Date: Tuesday, May 8, 2007, 3:00 p.
As expected, serum TTR reductions were well correlated with parallel changes in retinol binding protein and vitamin A levels.
Alternative methods are based on the evaluation of individual biochemical variables, such as measurement of prealbumin (PAB) (9-11) or retinol binding protein (RBP) (12), or of multiple variables, as in the Prognostic Inflammatory and Nutritional Index (PINI) score (13), which includes evaluation of albumin, a1-acid glycoprotein, and C-reactive protein (CRP).
TTR, a transport protein for thyroxine and retinol binding protein, is produced primarily in the liver and circulates in the plasma as a tetramer.
Retinol binding protein in plasma to evaluate the hepatotoxicity of rats treated with CCI4.
Evaluation of drug-induced hepatotoxicity by plasma retinol binding protein.
Stability of al microglobulin /32 microglobulin and retinol binding protein in urine.
Use of retinol binding protein and prealbumin as indicators of the response to nutrition therapy.
Paediatric reference ranges for prealbumin and retinol binding protein.
Retinol binding protein as a small molecular weight marker of renal tubular function in diabetes mellitus.