retinoic acid syndrome


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retinoic acid syndrome

complex of symptoms in patients taking all-trans retinoic acid for acute promyelocytic leukemia; comprises fever, dyspnea, weight gain, pulmonary infiltrates, pleural or pericardial effusions, episodic hypotension, renal dysfunction, and leukocytosis.

retinoic acid syndrome

A potentially fatal complication of all-trans retinoic acid (ATRA, tretinoin) therapy, which is seen in patients with acute promyelocytic leukemia, and characterised by fever, dyspnoea, weight gain, pulmonary infiltrates and pleural or pericardial effusions, ± leukocytosis.

Management
High-dose steroids (dexamethasone) begun at first signs of retinoic acid syndrome (e.g., unexplained fever, dyspnoea, weight gain, abnormal chest auscultatory findings or radiographic changes), irrespective of leukocyte count, continued for 3+ days until signs and symptoms have abated.
References in periodicals archive ?
2), (6) Side effects of retinoic acid syndrome are of concern, and patients must also be monitored for risk.
ATRA has been associated with retinoic acid syndrome (RAS), a serious and sometimes fatal complication that occurs in up to 25 percent of patients due to a rapid increase in white blood cells.
Some patients with APL treated with TRISENOX(R) have experienced differentiation syndrome -- with symptoms similar to retinoic acid syndrome.

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