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retinoic acid embryopathy

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retinoic acid embryopathy
Perinatology A teratogenic complex induced by retinoic acid, a vitamin A analogue, resulting in a 26-fold ↑ of congenital defects–eg, microtia, anotia, cleft palate, cardiac–conotruncal and aortic arch, neural crest, craniofacial, thymic defects, hyperostoses, retinal and optic nerve abnormalities, CNS malformations, premature closure of the epiphyseal plates; an identical embryopathy occurs with 'megadose' ingestion of vitamin A


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