KDM5B

(redirected from retinoblastoma-binding protein 2, homolog 1A)

KDM5B

A gene on chromosome 1q32.1 that encodes lysine-specific demethylase 5B, which interacts with FOXG1 and PAX9 as a transcriptional co-repressor. Lysine K-specific methylase may act as a tumour suppressor for melanoma.

Molecular pathology
KDM5B favours breast cancer cell proliferation by repressing tumour suppressor genes BRCA1 and HOXA5.
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