The results of pulmonary function tests showed decreased diffusion capacity (n=4), restrictive ventilatory defect (n=3), moderate obstructive ventilatory defect (n=1) and were completely normal in 1 patient.
Clinical characteristics of the cases Clinical characteristics Number of cases (n) Cough 4 Dyspnea 4 Sputum 3 Fever 3 Weight loss 3 Hemoptysis 1 Bilateral inspiratory crackles 4 Normal physical examination 1 Decreased diffusion capacity 4 Restrictive ventilatory defect 3 Obstructive ventilatory defect 1 Normal pulmonary function 1 Bilateral infiltrations 4 Focal opacity 1 Transthoracic biopsy 4 Transbronchial biopsy 1
Unfortunately, pulmonary edema can cause both a restrictive ventilatory defect
and an elevated DLCO.
Classically, a restrictive ventilatory defect (restriction) is defined as a reduced total lung capacity (TLC).
In a following study from the same laboratory, Glady developed an algorithm to predict the presence of a restrictive ventilatory defect in individual patients.