El, the active ingredient, is an inflammation-resolving molecule.
Treatment with a single dose of a DHA-derived resolvin
protected the brain from memory dysfunction after surgery by "resolving" neuroinflammation.
They added either an active form of vitamin D3 called 1 alpha, 25-dihydroxyvitamin D3 or an active form of DHA called resolvin
D-1 to some of the cells to gauge the effect they had on inflammation and amyloid-beta absorption.
DI and resolvin
D2 govern local inflammatory tone in obese fat.
18R/S-hydroxy-5Z,8Z,11Z,14Z,16E-eicosapentaenoic acid (18R/S-HEPE); 17S-hydroxy-4Z,7Z,10Z,13Z,15E, 19Z-docosahexaenoic acid (17S-HDHA); 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z- docosahexaenoic acid (RvD1 or Resolvin
D1); 7S,8R,17R-trihydroxy 4Z,9E,11E,13Z,15E19Z-docosahexaenoic acid (17R RvD1 or 17R-Resolvin
D1); 7S,16R,17S-trihydroxy4Z,8E,10Z,12E,14E,19Z- docosahexaenoic acid (RvD2 or Resolvin
D2); 10S,17S-dihydroxy-4Z,7Z,11E,13Z,15E, 19Z-docosahexaenoic acid (10S,17S-diHDHA); and leukotriene [B.
El and protectin D1 activate inflammation-resolution programmes.
Researchers found the body converts a fatty acid in fish oils into a powerful anti-inflammatory biochemical called resolvin
the leading resolvin
therapeutics company, today announced the presentation of data on its novel resolvins
for the treatment of both ocular surface diseases and retinal diseases at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting in Fort Lauderdale, Florida, being held May 2-6, 2010.
Charles Serhan of Brigham and Women's Hospital and Harvard Medical School said "In this report, we found that one resolvin
, termed resolvin
D3 from the omega-3 fatty acid DHA, persists longer at sites of inflammation than either resolvin
D1 or resolvin
D2 in the natural resolution of inflammation in mice.
El regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo.
RX-10045, a resolvin
administered as a topical eye drop, produced dose-dependent, significant improvement on the primary endpoints for both the signs and symptoms of dry eye, and was generally shown to be safe and well tolerated in a large placebo-controlled Phase II study.
The DHA omega-3 also reduces proinflammatory mediators such as prostaglandin E2, thromboxanes, and leukotrienes, and increases the production of anti-inflammatory compounds such as lipoxins and resolvin
along with substances that protect brain cells called neuroprotectins (see figure 3 on page 51).