resistin


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re·sis·tin

(rē-zis'tin),
Cytokine secreted by adipocytes into the circulation; causes resistance of peripheral tissues to insulin; possible link between obesity and Type 2 diabetes mellitus.
[resist + in]

RETN

A gene on chromosome 19p13.2 that encodes resistin, which is secreted by adipocytes and suppresses insulin-driven glucose uptake by adipose cells.

Molecular pathology
RETN mutations may link obesity to type-2 diabetes.

resistin

(rē-zĭs′tĭn)
A cysteine-rich peptide hormone, secreted by fat, that decreases cell sensitivity to the effects of insulin.

re·sis·tin

(rē-zis'tin)
Cytokine secreted by adipocytes into the circulation; causes resistance of peripheral tissues to insulin; possible link between obesity and Type 2 diabetes mellitus.
References in periodicals archive ?
Resistin, interleukin-6, tumor necrosis factor-alpha, and human semen parameters in the presence of leukocytospermia, smoking habit, and varicocele.
1[beta]-Hydroxy-2-oxopomolic acid, isolated from Agrimonia pilosa, has been reported to inhibit adipocyte differentiation and expression of several adipogenic marker genes, such as peroxisome proliferator activated receptor [gamma] (PPAR[gamma]), CCAAT-enhancer-binding protein a (C/EBP[alpha]), glucose transporter 4 (GLUT4), adiponectin, adipocyte fatty acid-binding protein 2 (aP2), adipocyte determination and differentiation factor 1/sterol regulatory element binding protein 1c (ADDl/SREBP1c), resistin and fatty acid synthase (Fas) in pre-adipocytes.
Effect of olive oil consumption on serum resistin concentrations in healthy men.
Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer.
Hepatic enzyme, serum lipid levels, oxidative production, mitochondrial membrane fluidity, homeostasis model assessment-insulin resistance index (HOMA-IR), gene and protein expression of adiponectin, and resistin were evaluated by biochemical, reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis.
It has been shown that abnormal expression of PPAR[gamma] in fibroblasts induces the expression of a battery of genes including adipokines, leptin, resistin and the accumulation of triglyceride droplets (Tontonoz and Spiegelman, 2008).
And what it produces is inflammatory signals and abnormal cytokines, or cell-to-cell hormone signal molecules, such as leptin, resistin, and tumor necrosis factor.
In addition to NT-proBNP, plasma samples were measured for insulin, leptin, resistin, interleukin-6, free fatty acids, oxidized LDL cholesterol, creatinine, Hb A1c, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, high-sensitivity C-reactive protein (hsCRP), and soluble intercellular adhesion molecule 1 in a core laboratory certified by the National, Heart, Lung, and Blood Institute/CDC and Prevention Lipid Standardization Program.
Levels of four proteins secreted by adipose tissue - chemerin, resistin, visfatin and omentin-1 - were also measured in plasma and in subcutaneous fat samples from gluteal tissue.