resistin


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re·sis·tin

(rē-zis'tin),
Cytokine secreted by adipocytes into the circulation; causes resistance of peripheral tissues to insulin; possible link between obesity and Type 2 diabetes mellitus.
[resist + in]

RETN

A gene on chromosome 19p13.2 that encodes resistin, which is secreted by adipocytes and suppresses insulin-driven glucose uptake by adipose cells.

Molecular pathology
RETN mutations may link obesity to type-2 diabetes.

resistin

(rē-zĭs′tĭn)
A cysteine-rich peptide hormone, secreted by fat, that decreases cell sensitivity to the effects of insulin.

re·sis·tin

(rē-zis'tin)
Cytokine secreted by adipocytes into the circulation; causes resistance of peripheral tissues to insulin; possible link between obesity and Type 2 diabetes mellitus.
References in periodicals archive ?
Resistin, interleukin-6, tumor necrosis factor-alpha, and human semen parameters in the presence of leukocytospermia, smoking habit, and varicocele.
It has been documented by various resent studies that the adipose tissue is not just a fat deposit but it also acts as an endocrine tissue and produces numerous hormone like proteins called adipokines including: leptin, adiponectin, vaspin, TNFa, IL 6, IL 10, resistin, visfatin and omentin.
4 and 2 mg/kg for 5 or 13 wk had no effect on the serum levels of adipokines closely related with energy balance such as leptin, adiponectin, or resistin (Howell et al.
Leptin, resistin, and visfatin, formed and released by white adipose tissue, and oxidized low density lipoprotein (OxLDL), have actions in the cartilage that are similar to those of IL-1[beta], TNF-[alpha] and IL-6.
31) Some of the deleterious renal consequences of obesity may be mediated by downstream comorbid conditions such as diabetes mellitus or hypertension, but there are also effects of adiposity which could impact the kidneys directly, induced by the endocrine activity of the adipose tissue via production of (among others) adiponectin (32), leptin (33) and resistin (34) (Figure 1).
Radioimmunology kits (China Institute of Atomic Research, Beijing, China) specific for pig insulin, adiponectin, IL-6, resistin and TNF-[alpha] were used.
Leptin, resistin and visfatin: the missing link between endocrine metabolic disorders and immunity.
When visceral adiposity enlarges, it increases production of free fatty acids and adipokines, such as tumor necrosis factor-[alpha] (TNF-[alpha]), resistin, and interleukin-6 (IL-6), and decreases levels of insulin-sensitizing adiponectin.
Diabetes mellitus is associated with an increased expression of resistin in human pancreatic islet cells.