reproductive toxicity


Also found in: Encyclopedia.

reproductive toxicity

Any adverse effect attributable to exposure to a chemical, directed against the reproductive and/or related endocrine systems Adverse effects Altered sexual behavior, fertility, pregnancy outcomes, or modifications in other functions that depend on reproductive integrity of system. See Teratogenicity.
Mentioned in ?
References in periodicals archive ?
5) Little research has been conducted on the reproductive toxicity of these chemicals in mixture, (6) which reflects the most realistic exposure.
This animal species is not commonly used in reproductive toxicity studies for regulatory purposes.
This suggests that a negative effect on chromatin condensation of the sperm could be another mechanism by which sulfasalazine exposure leads to reproductive toxicity.
Although the authors of the new study caution that previous studies on ethylene oxide's reproductive toxicity have had limited sample sizes, these effects have been documented in peer-reviewed studies, some dating back to the 1980s.
Their topics include what chemicals are and what harm they cause, how toxicology is studied, mutagenesis and carcinogenesis, developmental and reproductive toxicity, epidemiology, and the study of risk.
In a reproductive toxicity study in rats and rabbits, Defibrotide given by 2-hour infusion showed maternal toxicity with effects on pregnancy and intrauterine development of the progeny, while effects on embryofetal development could not be determined.
This study, according to evaluation of raw data by Gallagher, revealed signs of inflammation, allergy, tissue injury, liver damage, reproductive toxicity and chronic infection and even blood cancer.
And while the meeting was able to conclude there was a low risk of BPA causing harm in a string of important health issues--concluding for instance that studies on "developmental and reproductive toxicity .
These results therefore support the suggestion that treatment with VC reversed the adverse reproductive toxicity effect associated with exposure to GV in female rats.
But the state does have a unique law, Proposition 65, which states that "no person in the course of doing business shall knowingly and intentionally expose any individual to a chemical known to the state to cause cancer or reproductive toxicity without first giving clear and reasonable warning to such individual.
The list of unregulated pollutants includes the rocket fuel ingredient perchlorate which has been linked to thyroid toxicity, the gasoline additive known as MTBE and associated with liver and kidney damage, the plastic plasticizer di-n-butylphthalate linked to birth defects and reproductive toxicity, and the radioactive gas radon.
And, in February, California's Environmental Protection Agency indicated that it was considering including BPA on its list of chemicals known to cause cancer or reproductive toxicity, based on the NTP's findings.

Full browser ?