Long QT syndrome (LQTS) is an inherited channelopathy that affects the repolarizing
potassium currents or causes prolonged depolarization via "leaky" sodium channels in the myocyte, resulting in a prolonged QT interval on an electrocardiogram.
Lopinavir has been shown to block the repolarizing
In this phase, the heart has depolarized but is not actively repolarizing
hERG which encodes the potassium ion channel is considered responsible for repolarizing
IKr current in the cardiac action potential.
sup], I [sub]to is the main current contributing to the repolarizing
phase 1 of the AP.
Changes in AP shape and duration result from alteration in the functional expression of depolarizing and repolarizing
2]-muscarinic receptors are known to be expressed in the heart, and the cholinergic stimulation of this organ decreases the rate of the spontaneous diastolic depolarization, as well as increasing the repolarizing
current at the SA node (Di Francesco, 1993), we suggest that OEMV could decrease heart rate by stimulation of cardiac [M.
delaying agents also are just entering clinical studies and must show their potential in proof-of-concept tests.