replisome


Also found in: Wikipedia.

replisome

complex formed by the association of the main proteins involved in DNA replication. see DNA.
Mentioned in ?
References in periodicals archive ?
Thus, the object of my proposal is to identify novel factors involved in normal DNA replication progression and the response to replicative stress at the replisome level, specifically in human cells.
13-15) In vitro experiments showed a minimal mtDNA replisome of a heterotrimeric DNA polymerase, which consists of a catalytic subunit (pol [gamma]A) and a homodimer of the accessory subunit (pol [gamma]B), a helicase (Twinkle, encoded by PEO1 [C10ORF2]) and a mitochondrial single-stranded DNA-binding protein (mtSSB).
As an essential protein in the mtDNA replisome, it greatly enhances pol [gamma] activity.
A sampling of topics: adventures in physical chemistry, simplified models of biological networks, eukaryotic mechanosensitive channels, theoretical perspectives on protein folding, the protein shell structure and evolution of bacterial microcompartment organelles, phase separation in biological membranes, expanding roles for diverse physical phenomena during the origin of life, structure and activation of the visual pigment rhodopsin, single-molecule studies of the replisome, chromatin dynamics, synthetic biology as a tool to integrate the organizational principles of living systems, structural and functional insights into the myosin motor mechanism, and lipids and cholesterol as regulators of traffic in the endomembrane systems.
NIGMS mission areas include, but are not limited to, the following: 1) signaling networks and the regulatory dynamics of cellular processes such as cell cycle control, transient complex formation, organelle biogenesis, and intercellular communications; 2) supramolecular machines, such as the replisome, spliceosome, and molecular motor assemblies in cell division and motility; 3) pattern formation and developmental processes in model systems (e.
A principal component of the mtDNA replisome is the mtDNA polymerase [gamma].
Deficiency in any one of the 20 or so components of the mtDNA replisome could theoretically lead to mtDNA depletion, and we have reported a patient in whom mtDNA depletion was associated with deficient activity of mtDNA polymerase [gamma] (17).
The goal of this proposal is to shed light onto how DNA replication initiates and the replisome elongates on chromatin.
These experiments will shed light on the mechanochemical cycle of RNA polymerase, on its motion along a complex track, on the physical interactions that occur between helicases and proteins at termination, and on replisome dynamics near stall.