cholerae O1 variants with additional circular replicons
may contribute to evolution of the bacteria in unexpected manners.
In addition, mevastatin was found to prevent selection of replicons
resistant to the non nucleoside inhibitor HCV-796 (149).
The test indicated that the modified virus, called a replicon
, was delivering its genetic cargo to neurons and that these genes directed the cells to produce and release abundant amounts of the specified protein, the researchers report in the September NATURE BIOTECHNOLOGY.
On April 17, Dr Veronique Zennou, a Pharmasset scientist, will present a poster entitled "Combination of two complementary nucleotide analogues PSI-7977 and PSI-938 effectively clears wild type and NS5B S282T HCV replicons
- comparison with combinations of other antiviral compounds" (Poster 1034).
typing through a published multiplex PCR system revealed a replicon
I1 from the Tn6092harboring resistance plasmids in SC-B134 and SC-B136 (Table 1; Figure 2, panel C) (10).
The most active compounds display HCV replicon
EC50 potencies under 100 nanomolar in both genotypes 1a and 1b, the most prevalent and difficult to treat HCV genotypes.
(13), whereas Typhimurium plasmid R7 contained the II replicon
Katherine Holden from the School of Public Health, University of California, Berkeley, will present "Translation and RNA Synthesis of Dengue Virus Reporter Replicons
Are Inhibited by Antisense Morpholino Oligomers," an expansion of efforts in dengue virus previously performed by the Centers for Disease Control and Prevention (CDC).
CTX-M-15] and for different F replicons
(FII, FIA, FIB), which were obtained by PCR as described (19).
ANA598 is a low-nanomolar inhibitor of HCV genotype 1a and 1b replicons
potencies are superior to the most advanced clinical-stage small molecule protease inhibitors of Hepatitis C, which to date have reported triple-digit nM potency against 1a and 1b replicons
typing (PBRT), which recognizes FIA, FIB, FIE, HI1, HI2, Il-IT[gamma], L/M, N, P, W, T, A/C, K, B/O, X, Y, and FII replicons
(9), was applied to type the resistance plasmids from all the strains.