replicon

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rep·li·con

(rep'li-kon),
1. A segment of a chromosome (or of the DNA of a chromosome or similar entity) that can replicate, with its own initiation and termination codons, independently of the chromosome in which it may be located.
2. The replication unit; several are found per DNA in eukaryotic systems.
[replication + -on]

replicon

(rĕp′lĭ-kŏn′)
n.
A genetic element that undergoes replication as an autonomous unit.

replicon

[rep′ləkon]
Etymology: L, replicare
a segment of DNA that is undergoing replication. It is regulated by a section of the molecule called the regulator, which controls replication and coordinates it with cell division.

rep·li·con

(rep'li-kon)
1. A segment of a chromosome (or of the DNA of a chromosome or similar entity) that can replicate, with its own initiation and termination codons, independently of the chromosome in which it may be located.
2. The replication unit; several are found per DNA in eukaryotic systems.
[replication + -on]

replicon

a DNA molecule containing an ORIGIN OF REPLICATION necessary for initiating REPLICATION.
References in periodicals archive ?
cholerae O1 variants with additional circular replicons may contribute to evolution of the bacteria in unexpected manners.
In addition, mevastatin was found to prevent selection of replicons resistant to the non nucleoside inhibitor HCV-796 (149).
The test indicated that the modified virus, called a replicon, was delivering its genetic cargo to neurons and that these genes directed the cells to produce and release abundant amounts of the specified protein, the researchers report in the September NATURE BIOTECHNOLOGY.
On April 17, Dr Veronique Zennou, a Pharmasset scientist, will present a poster entitled "Combination of two complementary nucleotide analogues PSI-7977 and PSI-938 effectively clears wild type and NS5B S282T HCV replicons - comparison with combinations of other antiviral compounds" (Poster 1034).
Replicon typing through a published multiplex PCR system revealed a replicon I1 from the Tn6092harboring resistance plasmids in SC-B134 and SC-B136 (Table 1; Figure 2, panel C) (10).
The most active compounds display HCV replicon EC50 potencies under 100 nanomolar in both genotypes 1a and 1b, the most prevalent and difficult to treat HCV genotypes.
2] replicons (13), whereas Typhimurium plasmid R7 contained the II replicon.
Katherine Holden from the School of Public Health, University of California, Berkeley, will present "Translation and RNA Synthesis of Dengue Virus Reporter Replicons Are Inhibited by Antisense Morpholino Oligomers," an expansion of efforts in dengue virus previously performed by the Centers for Disease Control and Prevention (CDC).
CTX-M-15] and for different F replicons (FII, FIA, FIB), which were obtained by PCR as described (19).
These replicon potencies are superior to the most advanced clinical-stage small molecule protease inhibitors of Hepatitis C, which to date have reported triple-digit nM potency against 1a and 1b replicons.
PCR-based replicon typing (PBRT), which recognizes FIA, FIB, FIE, HI1, HI2, Il-IT[gamma], L/M, N, P, W, T, A/C, K, B/O, X, Y, and FII replicons (9), was applied to type the resistance plasmids from all the strains.