replicase


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rep·li·case

(rep'li-kās),
1. Descriptive term for RNA-directed RNA polymerase associated with replication of RNA viruses.
2. An enzyme that replicates nucleic acids.

replicase

/rep·li·case/ (rep´lĭ-kās)
1. a polymerase synthesizing RNA from an RNA template.
2. more generically, any enzyme that replicates nucleic acids, i.e., a DNA or RNA polymerase.

replicase

(rĕp′lĭ-kās′, -kāz′)
n.
Any of various enzymes that catalyze the synthesis of an RNA molecule from an RNA template (as in a virus) or a DNA molecule from a DNA template.

rep·li·case

(rep'li-kās)
Descriptive term for RNA-directed RNA polymerase (EC 2.7.7.48) associated with replication of RNA viruses.

replicase

or

RNA synthetase

an RNA-dependent RNA POLYMERASE ENZYME produced by some RNA VIRUSES for replication of the RNA genome.
References in periodicals archive ?
Broad resistance to tobamoviruses is mediated by a modified tobacco mosaic virus replicase transgene.
Amplification Methods - Polymerase Chain Reaction - Temperature Cyclers - PCR Variations * Immuno-PCR * QC-PCR * DAP-PCR - Strand Displacement Activation - TMA - Ligase Chain Reaction - Branched DNA - Hybridization Protection Assay - Nucleic-Acid Sequence-Based Amplification - Self-Sustained Sequence Replicase - Others - Ampliprobe - CAR - CAS - CPT - Dendritic Polymer Technology - ISO-CR - LAT - Probe Networks - RAMP - Repair Chain Reaction - Rolling Circles - Sequence Independent Gene Amplification - Sequence Initiation Reaction - SISPA - Solid Phase Amplification C.
Nonstructural protein 2 (Nsp2) and ORF5 are the most variable regions (4,5), coding for replicase protein and neutralizing epitope, respectively.
Probe/signal amplification methods include branched DNA (8), the Invader[R] assay (9), rolling circle amplification (10), and Q-beta replicase (11).
Inhibitors of the HCV NS5A protein represent an exciting, highly potent class that is mechanistically distinct from other classes of direct-acting HCV antivirals that target the viral protease or replicase (polymerase).
Amplification Methods - PCR - Ligase Chain Reaction - Branched DNA - Q-Beta Replicase - NASBA - SDA - 3 SR - HPA - Two-Tiered System - LAT 8.
gt;96% aa identity in the key replicase 1ab domains), TGEV, FCoV, and CCoV should not be considered separate viruses.
Initially described in 1988 [147], the Q[beta] replicase system is based on the incorporation of a single-stranded oligonucleotide probe into an RNA molecule that can be exponentially amplified after target hybridization by the enzyme Q[beta] replicase [148].
Inhibitors of the HCV NS5A protein represent a promising new class of HCV antivirals that are mechanistically distinct from HCV agents that target the viral protease or replicase (polymerase).
Inhibitors of the HCV NS5A protein represent an exciting, highly potent class that is distinct from other classes of HCV antivirals that target the viral protease or replicase.
The causes for the strikingly different patterns of genetic diversity observed in these 2 viral systems could include 1) increased movement of WNV-infected birds or mosquitoes compared with EEEV-infected birds or mosquitoes, leading to more frequent introduction of novel genotypes, 2) a higher replicase error rate, and 3) relaxed selective constraint in hosts or vectors of WNV relative to EEEV.
The highly neuroinvasive strain SPU 116/89 had mutations that may alter the hydrophobicity of the NS4B protein (Ala79Thr) relative to the other strains and may have potential structural and functional implications for the viral replicase complex of which NS4B is a component (25).