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Reperfusion Injury

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Reperfusion Injury
Cardiology Myocardial injury caused by rapid flow of blood into areas previously rendered ischaemic by coronary artery occlusion. Reperfusion injury is attributed to oxidative stress, which may cause arrhythmia, infarction, myocardial stunning
Traumatology A component of crush syndrome, which occurs when blood flow is re-established to an organ or tissue exposed to prolonged ischaemia; renewed blood flow aggravates tissue damage either by causing additional injury or by unmasking injury sustained during the ischaemic period. Reperfusion injury occurs in the heart, intestine, kidney, lung, and muscle, and is due to microvascular damage

reperfusion injury
damage to renal blood vessels during periods of hypotension does not become apparent until reperfusion occurs in the recovery stage of the vascular incident.

reperfusion injury
Cardiology Myocardial injury caused by rapid flow of blood into areas previously rendered ischemic by coronary artery occlusion; RI is attributed to oxidative stress, which may cause arrhythmia, infarction, myocardial stunning. See Reperfusion Traumatology A component of crush syndrome, which occurs when blood flow is reestablished to an organ or tissue exposed to prolonged ischemia; renewed blood flow aggravates tissue damage either by causing additional injury or by unmasking injury sustained during the ischemic period; RI occurs in the heart, intestine, kidney, lung, and muscle, and is due to microvascular damage. See Calcium paradox, Oxygen paradox.


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Strategies are then reviewed for rescue coronary intervention for failed thrombolysis, facilitated percutaneous coronary intervention, and preserving microvascular integrity and preventing reperfusion injury.
Reperfusion injury is characterised by the production of reactive oxygen species (ROS), including superoxide, hydrogen peroxide, and hydroxyl radical.
A primary factor in the initiation of the pathological response to reperfusion injury is the generation of high levels of ROS, which can covalently modify protein and lipid maeromolecules leading to cell damage, DNA mutaiton, and initiation of apoptotic and necrotic cascades (Greenlund et al.
 
 
 
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