reperfusion injury


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re·per·fu·sion in·ju·ry

myocardial impairment, usually with arrhythmia, following the opening of arterial blockage and considered to be due to oxygen-derived free radicals.
Cardiology Myocardial injury caused by rapid flow of blood into areas previously rendered ischaemic by coronary artery occlusion. Reperfusion injury is attributed to oxidative stress, which may cause arrhythmia, infarction, myocardial stunning
Traumatology A component of crush syndrome, which occurs when blood flow is re-established to an organ or tissue exposed to prolonged ischaemia; renewed blood flow aggravates tissue damage either by causing additional injury or by unmasking injury sustained during the ischaemic period. Reperfusion injury occurs in the heart, intestine, kidney, lung, and muscle, and is due to microvascular damage

reperfusion injury

Cardiology Myocardial injury caused by rapid flow of blood into areas previously rendered ischemic by coronary artery occlusion; RI is attributed to oxidative stress, which may cause arrhythmia, infarction, myocardial stunning. See Reperfusion Traumatology A component of crush syndrome, which occurs when blood flow is reestablished to an organ or tissue exposed to prolonged ischemia; renewed blood flow aggravates tissue damage either by causing additional injury or by unmasking injury sustained during the ischemic period; RI occurs in the heart, intestine, kidney, lung, and muscle, and is due to microvascular damage. See Calcium paradox, Oxygen paradox.

reperfusion injury

The damage, and loss of function, that commonly occurs in the heart muscle when, after a heart attack, the flow of blood to the muscle is restored. Reperfusion injury is generally agreed to be due mainly to the action of oxygen FREE RADICALS. It is also known as myocardial stunning.

reperfusion injury

damage to renal blood vessels during periods of hypotension does not become apparent until reperfusion occurs in the recovery stage of the vascular incident.
References in periodicals archive ?
Cyclosporine has already shown the potential to reduce significantly the level of reperfusion injury and we are looking forward to confirming this important finding in the current CIRCUS study.
Protective effect of folic acid against apoptosis induced by Ischemia/ reperfusion injury in rat liver.
A review of the Reperfusion Injury products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
CicloMulsion, a Cremophor-free formulation of the cyclophilin inhibitor cyclosporine, is in clinical development by NeuroVive for the treatment of cardiac reperfusion injury.
GlobalData's clinical trial report, Reperfusion Injury Global Clinical Trials Review, H1, 2012" provides data on the Reperfusion Injury clinical trial scenario.
Stealth's Phase II clinical study, EMBRACE-STEMI[TM] (Evaluation of the Myocardial effects of Bendavia for reducing Reperfusion injury in patients with Acute Coronary Events), is scheduled to enroll 300 patients across 40 sites within the United States and Europe.
The research studied reperfusion injury and Bendavia's ability to preserve viable and compromised myocardium, while independently reducing the area of microvascular dysfunction associated with the "no-reflow" phenomenon.
Robert Kloner's laboratory, led by Sharon Hale, Heart Institute of Good Samaritan Hospital, presented animal data on Bendavia for acute myocardial infarction (AMI) and its ability to preserve viable and compromised myocardium after ischemia reperfusion injury, while independently reducing the area of microvascular dysfunction associated with the often termed "no-reflow" phenomenon.
We believe that InnerCool's low-profile, high-performance endovascular cooling system has the capacity to achieve rapid cooling within the short time available before coronary reperfusion must occur in order to potentially limit the amount of damage due to reperfusion injury following heart attack," stated Christopher J.
Standard animal models for AMI demonstrate Bendavia's beneficial myocardial effects and confirm the significance of its novel mechanism of action, which preserves mitochondrial function under pathological conditions, for ischemia reperfusion injury.