reperfusion


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Related to reperfusion: reperfusion arrhythmia

reperfusion

 [re″per-fu´zhun]
restoration of blood flow to an area or part that had had temporary ischemia.

reperfusion

(rē′pər-fyo͞o′zhən)
n.
The restoration of blood flow to an organ or tissue that has had its blood supply cut off, as after a heart attack.

reperfusion

[rē′pərfyo̅o̅′zhən]
blocked arteries are opened to reestablish blood flow. It may be accomplished through thrombolytic therapy or percutaneous transluminal angioplasty.

reperfusion

(re-per-fu'zhon) [ re- + perfusion]
1. The restoration of blood flow to a part of the body deprived of adequate circulation, e.g., the heart muscle in myocardial infarction or the brain in stroke. This may be accomplished by thrombolytic agents, (e.g., streptokinase or tissue plasminogen activator), or mechanical interventions (e.g., stent placement). These interventions have improved outcomes in patients with acute coronary syndromes and in patients with stroke who come to medical attention in the first few hours of their illness.
2. The reinstitution of blood flow to tissues that have been traumatized, esp. by a long period of crushing. See: crush syndrome; rhabdomyolysis
References in periodicals archive ?
Successful reperfusion was defined as recovery of the elevated ST segment.
Venous blood samples were collected to determine the apoptotic activity from the patients at the beginning of thrombolysis in myocardial infarction grade 3 of reperfusion in infarct-related artery according to thrombolysis in myocardial infarction classification, and after reperfusion provided at 6, 12, 24 and 72 hours.
Finally we were left with 40 patients who had successful reperfusion and had interpretable pre and post angioplasty ECG recordings.
The company added that the new expected patent will cover protection, treatment, inhibition or reduction of damaged of tissue due to the increase of blood flow while opening a blocked artery in the heart, also known as reperfusion injury, or in the central nervous system during the treatment of certain types of stroke.
Reperfusion is characterized by an early and a late phase, during which, due to reduced adenylate cyclase activity and intracellular cAMP levels, free radicals, such as ROS, are generated [4], and the mechanisms of cell death are triggered.
The phenomenon of reperfusion, by removing the agent causing the ischaemia, attempts to re-regulate the blood flow to the tissue thus providing the energy required by the ischaemic tissue and removing toxic metabolites.
Mark Roth, PhD, and colleagues examined the effects of selenium in mouse models of ischemia reperfusion injury.
In group 4 and 5, the LAD artery was ligated for 30 minutes followed by 10 minutes or 60 minutes reperfusion respectively.
This report provides comprehensive information on the therapeutic development for Reperfusion Injury, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
While their findings were in limb injuries, the researchers say they should translate to the myriad of scenarios resulting in reperfusion injury.
This article will explain the mechanisms by which ischaemia causes cellular damage, the phenomenon of reperfusion injury and what treatment options are available.