The rationale for CLARITY was that the efficacy of fibrinolytic therapy is limited by inadequate reperfusion and/or early reocclusion
in one-quarter of treated patients.
This rebound PAI-1 increase may interfere with thrombolytic therapy and may thus diminish the success of such interventions or may be responsible for spontaneous reocclusion
after successful reopening of the coronary vessel after thrombolysis.
Documented experience with reocclusion
following thrombolysis in the AMI population contributed to clinical concerns of reocclusion
of the cerebral vessels following clot lysis.
4 percent reocclusion
rate and the fish-oil group had only a 19 percent reocclusion
and adverse cardiovascular events after successful balloon angioplasty of occluded versus nonoccluded coronary arteries.
Stenting has never gained widespread acceptance in the superficial femoral artery (SFA) due to the high rate of early reocclusion
in previous series.
In the study entitled, "Determination of temporal expression patterns for multiple genes in the rat carotid artery injury model," published in Arteriosclerosis, Thrombosis and Vascular Biology, scientists at CVT employed real-time PCR technology to examine which genes are switched on or off as restenosis, a reocclusion
of vessels, develops in an animal model.
Three studies published in the March CIRCULATION attempt to clarify post-tPA reocclusion
and suggest solutions.
INTEGRILIN helps prevent reocclusion
of the stented artery by blocking certain receptors, known as GP IIb-IIIa, on platelets that are responsible for thrombus development.
In addition, the combination group had fewer clinical events, suggesting less reocclusion
Choy plans to use the laser procedure as soon as he finds someone with the right anatomy -- a patient with occluded (blocked) arteries too small to bypass or whose condition wouldn't be threatened by reocclusion
Once a renal artery is opened by angioplasty or stenting it has a substantially increased risk of reocclusion