renin-angiotensin system


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re·nin-an·gi·o·ten·sin sys·tem

a selective regulator of the aldosterone biosynthetic pathway that acts by increasing aldosterone production and sodium retention as a result of volume depletion, with resulting increased renin production in the kidney and conversion of angiotensin I in the plasma to angiotensin II.

renin-angiotensin system

the regulation of sodium balance, fluid volume, and blood pressure. In response to reduced perfusion, renin is secreted, which hydrolyzes a plasma globulin to release angiotensin I, which is rapidly hydrolyzed to angiotensin II, a powerful vasoconstrictor; angiotension II also stimulates aldosterone secretion, which causes sodium retention, an increase in blood pressure, and restoration of renal perfusion, which shuts off the signal for renin release (negative feedback). Angiotensin-converting enzyme also deactivates bradykinin, a vasodilator. Also called renin-angiotensin-aldosterone system.
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Renin-angiotensin system

re·nin-an·gi·o·ten·sin sys·tem

(RAS) (rē'nin-an-jē-ō-tensin sistĕm)
Selective regulator of the aldosterone biosynthetic pathway that acts by increasing aldosterone production and sodium retention due to volume depletion.

renin

a proteolytic enzyme synthesized, stored and secreted by the juxtaglomerular cells of the kidney; it plays a role in regulation of blood pressure by catalyzing the conversion of the plasma glycoprotein angiotensinogen to angiotensin I. This, in turn, is converted to angiotensin II by an enzyme that is present in relatively high concentrations in the lung. Angiotensin II is one of the most potent vasoconstrictors known, and also is a powerful stimulus of aldosterone secretion.

renin-angiotensin system
renin, secreted by the juxtaglomerular apparatus, activates the precursor angiotensinogen. This liberates angiotensin I, then angiotensin II, a vasoconstrictor and stimulant to the secretion of aldosterone.
big renin
a relatively inactive protein with a higher molecular weight than normal renin, which is activated after exposure to low pH or to proteolytic enzymes.
References in periodicals archive ?
The finding that the vitamin D hormone inhibits the renin-angiotensin system generated much excitement in the field.
1]R antagonist, indicating that the renin-angiotensin system may play an important role.
Blockade of the renin-angiotensin system with ACE inhibitors has provided effective treatment of these conditions; however, some of the adverse effects of ACE inhibitors appear to be unrelated to angiotensin II blockade.
The study was a double-blind, dose-ranging, placebo-controlled study of 89 subjects with diabetic nephropathy on stable doses of renin-angiotensin system (RAS) inhibitors for >2 months with urinary albumin-to-creatinine ratio (UACR) of 100-3000 mg/g, eGFR >20 mL/min/1.
1) The role of glucose in the renin-angiotensin system (RAS) has been discussed in the literature.
Use of a drug that blocks the renin-angiotensin system in patients with renal disease.
The current standard of care for CKD is treatment with blood pressure lowering agents that affect the renin-angiotensin system, including ACEi and ARBs.
Tenders are invited for Medicines Functional Gastrointestinal Disorders Counter; Alimentary Tract and Metabolism; Medicines Against Hyperacidity Related Disorders; Vitamins; Medications Used in Cardiology; Muscle Relaxants; Antimycotics for Systemic Use; Diuretics; Anti-Epileptic; Psycholeptics; Other Nervous System Drugs; Medicines for Renin-Angiotensin System.
Changes in renal function, including acute renal failure, can be caused by drugs that inhibit the renin-angiotensin system.
Additional antihypertensive drugs that do not block the renin-angiotensin system were used as needed to achieve blood pressure control of less than 130/80 mm Hg.