angiotensinogen

(redirected from renin substrate)

angiotensinogen

 [an″je-o-ten´sin-o-jen]
a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.

an·gi·o·ten·sin·o·gen

(an'jē-ō-ten-sin'ō-jen),
The substrate for renin whereon through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma.

angiotensinogen

/an·gio·ten·sin·o·gen/ (-ten-sin´o-jen) a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.

angiotensinogen

[-tensin′əjən]
a serum glycoprotein produced in the liver that is the precursor of angiotensin.

angiotensinogen

A 60-kD, 1453-residue glycoprotein (13% carbohydrate) of the alpha2 globulin fraction of plasma proteins, which is synthesised and released from the liver and cleaved in the circulation to form the biologically inactive angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme.

A-I is in turn cleaved to form active A-II by ACE, which causes contraction of vascular smooth muscle and thus raises blood pressure and stimulates aldosterone release from the adrenal glands; A-III is then broken down by angiotensinases. The angiotensinogen gene is located on 1q42-43, and is mutated in essential hypertension.

angiotensinogen

Renin substrate A 60 kD glycoprotein of the α2 globulin fraction of plasma proteins, which is synthesized and released from the liver, and cleaved in the circulation to form the biologically inactive, angiotensin I, a decapeptide split from the N-terminal by renin, a proteolytic enzyme. See Angiotensin, Renin-angiotensin system.

an·gi·o·ten·sin·o·gen

(an'jē-ō-ten-sin'ō-jen)
The substrate for renin from which through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma.

angiotensinogen

an inactive precursor of ANGIOTENSIN; it is a large protein synthesized by the liver, secreted into the bloodstream and converted into angiotensin by RENIN.

angiotensinogen

a serum α2-globulin secreted in the liver which, on hydrolysis by renin, gives rise to angiotensin.
References in periodicals archive ?
Renin catalyzes the formation of angiotensin I (AngI) by cleavage of the renin substrate called angiotensinogen.
Results of a head-to-head scientific study comparing a menopausal hormone patch to a pill suggest that there may be significant differences in the way women respond to different routes of delivery, specifically as it affects the quality of their sex lives, and renin substrate levels, which may impact blood pressure.
Our study found women using CombiPatch experienced greater improvements in sexual quality of life and lower renin substrate levels, when compared to Prempro users.
However, some undesirable changes also are seen, such as those that occur in renin substrate, cortisol-binding globulin, and thyroid-binding globulin," Dr Liu commented.
The first-pass effect also has an impact on other end points, including renin substrate, Dr Liu said.
If the temperature of a specimen for plasma renin activity is allowed to rise above 4[degrees]C at any time during preparation for shipping, for example, renin substrate will be converted to angiotensin I and the value found will be incorrect.
Nasdaq:NOVN) today announced the availability of clinical data examining the effects of transdermal combination hormone replacement therapy (HRT) on the sexual quality of life of postmenopausal women and on renin substrate levels, which may impact blood pressure.
We purified renin substrate from hog plasma and found that it had several different forms (15).
Plasma prorenin: cryoactivation and relationship to renin substrate in normal subjects.
purification of several forms of renin substrate from hog plasma;
The plasma renin activity (PRA), measured by quantifying the Ang1 generated when plasma is incubated with endogenous renin substrate in the presence of converting enzyme inhibitors, can be used to reflect the activity of the renin-angiotensin system and may be useful in the diagnosis and management of hypertension (1).
However, to study disease states in which angiotensin formation is the critical issue, the PRA assay remains the gold standard because it incorporates the concurrent contribution of renin substrate to angiotensin formation and therefore is the most meaningful physiological and pathophysiological indicator of the activity of the renin-angiotensin system.