Renin

renin /re·nin/ (re´nin) a proteolytic enzyme synthesized, stored, and secreted by the juxtaglomerular cells of the kidney; it plays a role in regulation of blood pressure by catalyzing the conversion of angiotensinogen to angiotensin I.

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re·nin (rnn, rnn)

n.

A protein-digesting enzyme that is released by the kidneys and that catalyzes the hydrolysis of angiotensinogen to angiotensin I. Also called angiotensinogenase.

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Renin

An enzyme produced in the kidneys that controls the activation of the hormone angiotensin, which stimulates the adrenal glands to produce aldosterone.

Mentioned in: Aldosterone Assay

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renin

a proteolytic enzyme synthesized, stored and secreted by the juxtaglomerular cells of the kidney; it plays a role in regulation of blood pressure by catalyzing the conversion of the plasma glycoprotein angiotensinogen to angiotensin I. This, in turn, is converted to angiotensin II by an enzyme that is present in relatively high concentrations in the lung. Angiotensin II is one of the most potent vasoconstrictors known, and also is a powerful stimulus of aldosterone secretion.

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renin-angiotensin system

renin, secreted by the juxtaglomerular apparatus, activates the precursor angiotensinogen. This liberates angiotensin I, then angiotensin II, a vasoconstrictor and stimulant to the secretion of aldosterone.

big renin

a relatively inactive protein with a higher molecular weight than normal renin, which is activated after exposure to low pH or to proteolytic enzymes.