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renal clearance

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renal clearance
n.
The volume of plasma that is completely cleared of a specific compound per unit time, measured as a test of kidney function.

renal clearance
Therapeutics A hypothetical calculation of plasma volume in liters of unmetabolized drug cleared through the kidneys/unit time Factors influencing RC Renal blood flow, urinary pH, tubular resorption and secretion


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Therefore using an agent with both hepatobiliary and renal clearance properties is not recommended as a method of reducing NSF risk.
Moreover, elderly patients might have high offending drug concentrations due to decreased renal clearance, decreased hepatic metabolism, and polypharmacy-associated hepatic drug interactions (7).
Inhibition of p-glycoprotein decreases intestinal and renal clearance of digoxin, the most common example of which is the interaction between digoxin and quinidine.
 
 
 
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