Nitric oxide deficiency: Endothelial dysfunction is associated with decreased production, release, and availability of NO, also known as endothelium-derived relaxing factor
Shortly afterward it became clear that nitric oxide had important functions in the regulation of vascular tone, and it was demonstrated that nitric oxide was identical to endothelium-derived relaxing factor
, a factor derived from endothelial cells that induced relaxation of smooth muscle cells.
Endothelium produces potent vasodilators, such as endothelium-derived relaxing factor
(EDRF, NO), ptostacyclin and endothelium-derived hyperpolarizing factor (EDHF).
Nitrate is the measurable end point in serum used to assess levels of endothelium-derived relaxing factor
(EDRF), which in turn relates to nitric oxide levels.
By then, it was well established that NO is an endothelium-derived relaxing factor
But as Furchgott and Ignarro, working independently, analyzed the nature of the endothelium's relaxing factor
, the gas became a prime candidate.
In 1986, Ignarro suggested that a substance researchers were calling ``endothelium-derived relaxing factor
,'' which Furchgott had first described, was most likely nitric oxide.
It is well-established that NO is a major endothelium-derived relaxing factor
, both in vivo and in vitro (Moncada et al.
Endothelium-derived NO or a closely-related molecule was initially described as endothelium-derived relaxing factor
The researchers speculate that people with healthy blood vessels react to epinephrine's vessel-constricting message by stepping up production of a natural, nitroglycerine-like substance called endothelium-derived relaxing factor
Late last year, scientists reported on the activity of endothelium-derived relaxing factor
(EDRF), which prevents constriction of blood vessels (SN: 11/28/87, p.
Obese rats underwent improvements in the balance between constricting and relaxing factors
, indicating better endothelial function.