recombinant vaccine

recombinant vaccine,

a suspension of attenuated viruses or killed microorganisms developed through recombinant DNA techniques.

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vaccine

a suspension of attenuated or killed microorganisms (viruses, bacteria or rickettsiae), administered for prevention, amelioration or treatment of infectious diseases.

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anti-idiotype vaccine

antibody made to antigenic determinants located in the variable domains of immunoglobulin molecules. Proposed as a means of regulating antibody responses and also as a substitute antigen for vaccination.

vaccine-associated sarcoma

see sarcoma.

attenuated vaccine

a vaccine prepared from live microorganisms that have lost their virulence but retained their ability to induce protective immunity. Attenuated microorganisms including particularly bacteria and viruses may be found naturally or they may be produced in the laboratory, for example by adaptation to a new medium or cell culture or they may be produced by recombinant DNA technology.

autogenous vaccine

a vaccine prepared from cultures of material derived from a lesion of the animal to be vaccinated, e.g. wart vaccine.

bacterial vaccine

a preparation of attenuated or killed bacteria, used to immunize against organisms injected, or sometimes for pyrogenetic effects in treatment of certain noninfectious diseases.

biosynthetic vaccine

a formulation containing a protective, noninfectious, immunogenic subunit produced in or by a biological system.

caprinized vaccine

a vaccine, usually a virus, attenuated by serial passage through goats, e.g. caprinized rinderpest vaccine. In highly susceptible cattle this vaccine may cause significant reactions and lapinized vaccines are preferred.

core vaccine

one that should always be included in the basic immunization program for the species.

dead vaccine

inactivated vaccine; one with organisms that have been killed.

DNA vaccine

DNA sequences that code for immunogenic proteins located in appropriately constructed plasmids which include strong promoters, which when injected into an animal are taken up by cells and the immunogenic proteins are expressed and elicit an immune response. No vaccines of this type are licensed and concerns about safety have not been resolved.

heterotypic vaccine

one developed from a virus that is antigenically distinct but related to that causing the disease for which the animal is being immunized, e.g. measles vaccine used to protect dogs from canine distemper.

homotypic vaccine

one developed from the same virus as that causing the disease the animal is being immunized against.

human diploid cell vaccine

an inactivated rabies vaccine made from rabies virus grown on human embryo lung fibroblast cells.

inactivated vaccine

see dead vaccine (above).

killed virus (KV) vaccine

see dead vaccine (above).

live vaccine

a vaccine prepared from live, usually attenuated, microorganisms.

vaccine lymph

material containing vaccinia virus collected from vaccinial vesicles of inoculated calves; used for active immunization against smallpox.

mixed vaccine

see mixed bacterial vaccine.

modified live virus (MLV) vaccine

see attenuated vaccine (above).

polyvalent vaccine

one prepared from more than one strain or species of microorganisms.

recombinant vaccine

one created by recombinant DNA technology.

subunit vaccine

one containing only specific antigenic proteins of the infectious agent.

synthetic peptide vaccine

using synthetic short peptides which correspond with major epitopes of viral proteins to elicit a protective antibody response.

virus-vectored vaccine

use of viruses as vectors to carry selected genes from another virus for immunization.