recombinant tPA

recombinant tPA

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We currently are enrolling patients in a Phase 2 study of vepoloxamer in combination with recombinant tPA in patients with acute limb ischemia to assess whether vepoloxamer can accelerate time-to-reperfusion.
Recombinant tPA is approved for acute ischemic stroke in humans, however, its utilization is limited by its narrow therapeutic window and hemorrhagic complication.
Glycan structures of human recombinant tPA produced by Chinese hamster ovary cells have been reported to be core fucosylated and mono-, di-, and trisialylated (20-21).
025, and 0 ng/mL recombinant tPA, MME, DPP-4, and TIMP-1, respectively.
of Naples, Italy) notes that the only current drug therapy for stroke is a thrombolytic strategy aimed at reducing the failure of arterial oxygen and glucose delivery to the brain tissue by delivering the clot busting- drug recombinant tPA shortly after the onset of symptoms.
Food and Drug Administration for acute ischemic stroke, recombinant TPA, such as alteplase and reteplase, are being used off label for intraarterial lysis in ischemic stroke.
patents covering purified human tPA and recombinant tPA having the amino acid sequence of natural human tPA.
patents covering purified human tissue plasminogen activator (tPA) and recombinant tPA having the amino acid sequence of natural human tPA.

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