erythropoietin

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erythropoietin

 [ĕ-rith″ro-poi´ĕ-tin]
a glycoprotein hormone secreted by the kidney in the adult and by the liver in the fetus, which acts on stem cells of the bone marrow to stimulate red blood cell production (erythropoiesis).
recombinant human erythropoietin epoetin.

e·ryth·ro·poi·e·tin (EPO),

(ĕ-rith'rō-poy'ĕ-tin), [MIM*133170]
A protein containing sialic acid that enhances erythropoiesis by stimulating formation of proerythroblasts and release of reticulocytes from bone marrow; it is formed by the kidney and liver, and possibly by other tissues, and can be detected in human plasma and urine.

erythropoietin

/eryth·ro·poi·e·tin/ (-poi´ĕ-tin) a glycoprotein hormone secreted by the kidney in the adult and by the liver in the fetus, which acts on stem cells of the bone marrow to stimulate red blood cell production (erythropoiesis).
recombinant human erythropoietin  (r-HuEPO) epoetin.

erythropoietin

(ĭ-rĭth′rō-poi-ē′tĭn)
n.
1. A glycoprotein hormone that stimulates the production of red blood cells by stem cells in bone marrow. Produced mainly by the kidneys, it is released in response to decreased levels of oxygen in body tissue.
2. Epoetin alfa.

erythropoietin (EPO)

[erith′rōpō·ē′tin]
Etymology: Gk, erythros + poiein, to make
a glycoprotein hormone synthesized mainly in the kidneys and released into the bloodstream in response to anoxia. The hormone acts to stimulate and to regulate the production of erythrocytes and thus increases the oxygen-carrying capacity of the blood. See also erythropoiesis.

EPO

A gene on chromosome 7q22 that encodes erythropoietin, a secreted, glycosylated cytokine found in the plasma, which regulates red cell production by promoting erythroid differentiation and initiating haemoglobin synthesis. Erythropoietin plays a neuroprotective role in response to brain injury and is antiapoptotic.

Molecular pathology
Genetic variability of EPO has been linked to microvascular complications of diabetes type 2, including diabetic retinopathy, nephropathy leading to end-stage renal disease, and neuropathy

erythropoietin

EPO Physiology A 46 kD glycoprotein colony-stimulating factor produced predominantly by cells adjacent to the proximal renal tubules in response to signals from an oxygen-sensitive substances in the kidneys–eg, heme Adverse effects Chest pain, swelling, tachycardia, headache, HTN; erythropoietin–EP binds to receptors in erythroid precursors that mature into RBCs; EP is ↑ by hypoxia or by ectopic production from tumors–eg, cerebellar hemangioblastoma, hepatoma, pheochromocytoma, uterine leiomyoma, and renal cell carcinoma; it may not be ↑ in anemic premature infants, and is ↓ in 2º anemia, chronic inflammation, P vera, and certain CAs and may be useful in myeloma-related anemia; EP therapy is indicated for HIV-related anemia, anemia of renal failure and prematurity; it ↑ number of units of autologous RBCs that may be donated before surgery, for ↑ number of units that may be phlebotomized in Pts with hemochromatosis and to ↑ units that may be drawn from a person with a rare blood type

e·ryth·ro·poi·e·tin

(ĕ-rith'rō-poy'ĕ-tin)
A protein that enhances erythropoiesis by stimulating formation of proerythroblasts and releasing reticulocytes from bone marrow; secreted mainly by the kidney and possibly by other tissues.

Erythropoietin

A hormone produced by the kidneys that stimulates the production of red blood cells by bone marrow.
Mentioned in: Dialysis, Kidney

erythropoietin

kidney-derived protein promoting erythrocyte formation within bone marrow

erythropoietin

a glycoprotein hormone secreted mainly by the kidney. A profactor, erythropoietinogen, is first produced in the liver, transferred to the kidney and converted to active erythropoietin in the kidney. The erythropoietin acts on stem cells of the bone marrow to stimulate red blood cell production (erythropoiesis). Called also erythropoietin stimulating factor, erythrogenin.

recombinant erythropoietin
used to treat dogs and cats with nonregenerative anemia of renal disease; animals develop antibodies to the human product.
erythropoietin stimulating factor
see erythropoietin (above).
References in periodicals archive ?
Recombinant human erythropoietin in the treatment of acute ischemic stroke.
Novel erythropoiesis stimulating protein (NESP) effectively maintains hemoglobin (Hgb) when administered at reduced dose frequency compared with recombinant human erythropoietin (r-HuEPO) in ESRD patients (Abstract).
Efficacy of different dosing regimens for recombinant human erythropoietin in a simulated perisurgical setting: the importance of iron availability in optimizing response.
Novel erythropoiesis stimulating protein (NESP) corrects anemia in dialysis patients when administered at reduced dose frequency compared with recombinant human erythropoietin [abstract].
Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin in athletes.
A case of antierythropoietin antibodies following recombinant human erythropoietin treatment.
in Fort Worth, Texas has confirmed that a recombinant human erythropoietin, epoetin alfa, can reverse neural changes that cause chronic pain behavior.
Since the late 1980s, blood doping has been achieved through the administration of recombinant human erythropoietin (rHuEpo), a genetically engineered protein, which is structurally almost identical to the naturally occurring erythropoietin produced by the kidneys to stimulate red cell production," said Ian Giles, M.
the ITC has decided to institute an investigation of Roche's importation of pegylated recombinant human erythropoietin (peg-EPO) into the United States.
Currently, patients suffering from anemia receive chronic injections of recombinant human erythropoietin (EPO) protein to increase their red blood cell volume to a normal range.

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