recombinant DNA


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Related to recombinant DNA: recombinant DNA technology

re·com·bi·nant DNA

altered DNA resulting from the insertion into the chain, by chemical, enzymatic, or biologic means, of a sequence (a whole or partial chain of DNA) not originally (biologically) present in that chain.

recombinant DNA

n. Abbr. rDNA
Genetically engineered DNA prepared by transplanting or splicing genes from one species into the cells of a host organism of a different species. Such DNA becomes part of the host's genetic makeup and is replicated.

recombinant DNA

a DNA molecule in which rearrangement of the genes has been experimentally induced. Enzymes are used to break isolated DNA molecules into fragments that are then rearranged in the desired sequence. DNA sequences from another organism of the same or a different species may also be introduced into the molecule, which is then replicated, resulting in both genotypic and phenotypic alterations in the organism that carries the recombinant DNA. See also genetic engineering.

recombinant DNA

DNA produced by the artificial linkage, in the laboratory or factory, of DNA from different sources. See also GENETIC ENGINEERING.

recombinant DNA

  1. DNA produced by joining together DNA sequences from different sources in vitro; often this involves VECTOR (2) DNA and foreign DNA to form a recombinant vector for use in GENETIC ENGINEERING.
  2. DNA produced by natural RECOMBINATION in vivo.
References in periodicals archive ?
The committee also recommended that "[T]he RAC should continue to provide advice on policy matters revolving around gene therapy and other recombinant DNA issues to the NIH director, individual members of the research community, institutional review boards, and the public.
Recombinant DNA r-DNA, a DNA molecule that has been opened and recombined with altered genetic instructions.
Most recombinant DNA products on the market have been developed and approved under the provisions of the orphan drug bill.
Stryker Corporation (Kalamazoo, MI) has patented (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
The National Institutes of Health's Recombinant DNA Advisory Committee (RAC) voted to allow each team to squirt solutions of genetically engineered cold viruses into the nasal passages and lungs of patients.
Recombinant DNA molecules encoding the truncated insulin-like growth factor binding proteins are also described along with recombinant microorganisms and cell lines containing the DNA molecules and methods for producing the truncated insulin-like growth factor binding proteins using recombinant hosts containing the relevant DNA molecules.
Roth and his colleagues received approval from the NIH Recombinant DNA Advisory Committee to use the new gene-therapy procedure to treat 14 patients with advanced lung cancer.
Saticov, CA) has patented a chimeric recombinant DNA molecule comprising: a plurality of DNA sequences, each of which comprises a plant-functional promoter linked to a coding region, which encodes a virus-associated coat protein, wherein said DNA sequences are preferably linked in tandem so that they are expressed in virus-susceptible plant cells transformed with said recombinant DNA molecule to impart resistance to said viruses; as well as methods for transforming plants with the chimeric recombinant DNA molecule and for selecting plants which express at least one of said DNA sequences imparting viral resistance.

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