reagin


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reagin

 [re´ah-jin]
antibody of a specialized immunoglobulin class (IgE) which attaches to tissue cells of the same species from which it is derived, and which interacts with its antigen to induce the release of histamine and other vasoactive amines. A form of cytotropic antibody, it is present in the serum of naturally hypersensitive individuals and can confer specific immediate (type I) hypersensitivity in nonreactive individuals. adj., adj reagin´ic.

re·a·gin

(rē-ā'jin),
1. Wolff-Eisner term for antibody.
2. Old term for the "Wassermann" antibody; not to be confused with the Prausnitz-Küstner antibody.
3. Antibodies that mediate immediate hypersensitivity reactions (IgE in humans).

reagin

/re·a·gin/ (re´ah-jin) the antibody that mediates immediate hypersensitivity reactions; in humans, IgE.reagin´ic

reagin

(rē-ā′jĭn)
n.
1. An antibody found in the blood of individuals having a genetic predisposition to allergies.
2. A substance present in the blood of individuals having a positive serological test for syphilis.

re′a·gin′ic (rē′ə-jĭn′ĭk) adj.
re′a·gin′i·cal·ly adv.

reagin

[rē′ājin]
Etymology: L, re + agere
1 an antibody associated with human atopy, such as asthma and hay fever. It attaches to mast cells and basophils and sensitizes the skin and other tissues. In antigen-antibody reactions it triggers the release of histamine and other mediators that cause atopic symptoms.
2 a nonspecific, nontreponemal antibody-like substance found in the serum of individuals with syphilis. It can combine with an antigen prepared as a lipid extract of normal tissue, a phenomenon that constitutes the basis of the serological tests for syphilis. reaginic, adj.

re·a·gin

(rē-ā'jin)
1. Wolff-Eisner term for antibody.
2. Antibodies that mediate immediate hypersensitivity reactions (IgE in humans).
3. Synonym(s): homocytotropic antibody.

reagin(s) (rē´ājin),

n noncommittal term used for antibodies or antibody-like substances that differ in several respects from ordinary antibodies. It refers to the antibodies of allergic conditions (atopy) and to the antibody (reagin) concerned with the flocculation and complement fixation tests for syphilis.

reagin

an old term for immunoglobulin E antibody (IgE).

atopic reagin
the antibody responsible for hypersensitivity reactions to specific substances with signs of atopy resulting.
References in periodicals archive ?
Leslie Reagin, Vice President, Compensation, Benefits and Human Resource Services
Blood work Blood laboratory test Patient 1 Patient 2 CD4 count (cells/gL) 526 22 HIV PCR (copies/mL) 2,095,380 59,200 Rapid plasma reagin Negative Negative Human herpesvirus 6 PCR Negative N/A Herpes simplex virus PCR Negative Negative Varicella-zoster virus IgM Negative N/A Lyme antibody Negative N/A Monospot Negative N/A Cytomegalovirus PCR N/A Positive Toxoplasma IgG and IgM N/A Negative Thyroid-stimulating hormone Normal Normal Folic acid Normal Normal Vitamin B12 Normal Normal Serum protein electrophoresis Negative Negative Ganglioside antibody panel Negative N/A Heavy metal screen Negative Negative PCR indicates polymerase chain reaction; Ig, immunoglobulin.
The antinuclear factor (ANF), antineutrophil cytoplasmic antibody (ANCA), rapid plasma reagin (RPR) and rheumatoid factor (RF) were negative, and serum angiotensin converting enzyme (SACE) was 19 U/l.
The patient's test results were negative for gonorrhea, Chlamydia, and human immunodeficiency virus, with a nonreactive rapid plasma reagin test result in 2008.
Non-treponemal tests, including the rapid plasma reagin test and the venereal disease research laboratory test, have historically been used as the initial screening tests for the serologic diagnosis of syphilis.
Such results maybe associated with frequent transfusions, injection drug use, liver disease, multiple pregnancies, rheumatoid factor, lymphoma, multiple sclerosis, various autoimmune disorders, a positive result in the rapid plasma reagin test, and chronic hemodialysis (6).
By Nancy Reagin (New York and Cambridge: Cambridge University Press, 2007.
Investigations, including a computed tomography (CT) head scan, full blood count, HIV ELISA test, thyroid function test and rapid plasma reagin (RPR) screen were done but the results were unremarkable.
We needed a secure messaging infrastructure which tied together a comprehensive consumer portal with usage of our internal clinical and administrative systems to provide integrated access to information," said Mike Reagin, CTO of Providence Health & Services in Oregon.
The rapid plasma reagin test was nonreactive, and the vitamin [B.
Within 3 months, there was a fourfold reduction in serum rapid plasma reagin (RPR) titers with no increase in the follow-up period.