reactogenic

reactogenic

(rē-ak″tŏ-jen′ik) [ react(ion) + -genic]
Capable of producing a physiologic response, as a vaccine that elicits an antibody response.
reactogenicity (-jĕ-nis′ĭt-ē)
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References in periodicals archive ?
However, full exploitation of OMVs as vaccines is prevented by: i) presence of potentially reactogenic compounds such as LPS, virulence factors, and toxins, ii) presence of several irrelevant proteins, which dilute immune responses, iii) lack of broadly applicable molecular tools to load OMVs with foreign antigens.
Because of side effects of WCV, such as high rates of fever and local reactions, and variable efficacy of WCVs, a less reactogenic acellular vaccine (ACV) was developed in the 1980s.
botulinum being spore former, a dedicated facility is required; (ii) yields of toxin production are very low; (iii) the toxoiding process involves large quantities of toxin and thus dangerous; (iv) toxoid proteins are not purified thus other proteins may influence immunogenicity or reactivity of the vaccine; and (v) since the residual levels of formalin are part of the product formulation to prevent reactivation of toxin, the vaccine is reactogenic.
In this first direct comparison of an AS03B adjuvanted split virion versus whole virion non-adjuvanted H1N1 vaccine, the adjuvanted vaccine, while more reactogenic, was more immunogenic and, importantly, achieved high seroconversion rates in children aged less than 3 years.
Major Finding: Fluzone High-Dose influenza vaccine was more immunogenic and reactogenic than the standard dose in adults aged 65 years and older.
In addition, our novel adjuvant program is generating highly immunogenic adjuvants with improved reactogenic properties which will broaden protection across patient populations and minimize the amount of antigen required.
Tularemia Viral TC-83 is reactogenic in 20%; no encephalitides seroconversion seen in 20%; only effective against subtypes 1A, 1B, and 1C.
This vaccine is as efficacious as the wP vaccine, but the pertussis component is less reactogenic (2,3).
CpGoligonucleotides: Synthetic oligodeoxynucleotides containing immunostimulatory unmethylated CpG motifs, which are less reactogenic than CT, were investigated as a new candidate for H.
He writes in Hepato-Gastroenterology, "Anthrax vaccine, based upon our analysis of the VAERS, was one of the most reactogenic vaccines we have ever analyzed .
Tularemia Viral TC-83 is reactogenic in 20%; encephalitides no seroconversion seen in 20%; only effective against subtypes 1A, 1B, and 1C.
1mL) and changed to the less reactogenic Tokyo-172 strain (0.