gemistocytic astrocyte

(redirected from reactive astrocyte)

ge·mis·to·cyt·ic as·tro·cyte

a round to oval astrocyte cell with abundant cytoplasm containing glial filaments and an eccentric nucleus; may contain two nuclei in the cell; hypertrophy of astrocytes.


a neuroglial cell of ectodermal origin, characterized by fibrous or protoplasmic processes; collectively called astroglia or macroglia.

gemistocytic astrocyte
a plump astrocyte which results from injury to nervous tissue. Usually an extensive area is involved.
References in periodicals archive ?
Gliosis and more reactive astrocytes than usual were seen, some accumulating eosinophilic droplets.
Down-regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain.
He said that their research shows that the excessively high concentration of the GABA neurotransmitter in these reactive astrocytes is a novel biomarker that we hope can be targeted in further research as a tool for the diagnosis and treatment of Alzheimer's disease.
At the end of all this process, astrocytes are stimulated and observation of gemistocytes which are swelled reactive astrocytes and neuronal loss and gliosis in the striatal region in acute and chornic injuries in autopsy studies is explained in this way (9,11).
Reactive astrocytes could be observed in small developing metastasis as early as 7 days following tumor cell injection (Fig.
Studying the neuronal circuitry in brain slices from the mice, the study team found that changes in reactive astrocytes profoundly reduced the inhibitory control over brain signals.
Glial fibrillary acidic protein immunostains highlight the often evenly spaced reactive astrocytes and their processes.
Moreover, we noted that reactive astrocytes produced an extensive proliferation of fibrous processes and that the microglia assumed a phagocytic role.
These lesions may reveal hypercellularity and the presence of atypical reactive astrocytes with mitotic figures, which may be observed in these demyelinating lesions and be mistaken for an astrocytic neoplasm.
Kalderon speculates that the X rays destroy cells called reactive astrocytes, which may contribute to scarring at the site of a spinal cord injury and to the eventual degenerative response.
MAO-B activity is greatly upregulated in reactive astrocytes surrounding amyloid plaques in the brain of AD patients in comparison to age-matched controls.
In particular, we focused on the presence and distribution of both intracellular and extracellular A[Beta] protein, NFTs, activated microglia, and reactive astrocytes in the hippocampus and cerebral cortex.