ras oncogene


Also found in: Dictionary, Thesaurus, Encyclopedia.

ras oncogene

point mutations first described in rat sarcoma cells that can be shown to have transforming activity in culture as well as in tumorigenesis models in mice; the ras gene family is composed of three closely related genes on three different chromosomes; abnormalities have been identified in a variety of human tumors.

ras on·co·gene

(ras on'kō-jēn)
Point mutations first described in rat sarcoma cells that can be shown to have transforming activity in culture, as well as in tumorigenesis models in mice; the ras gene family is composed of three closely related genes on three different chromosomes; abnormalities have been identified in a variety of human tumors.
References in periodicals archive ?
Point mutations of ras oncogenes are an early event in thyroid tumorigenesis.
At the Keystone meetings, CTI investigators reported that LPAAT-beta function appears to be essential for the ability of the ras oncogene to enhance the cancer-causing potential of cells.
GRB2 has been a target for many pharmaceutical and biotech R&D programs because it is an activator (or, "adapter protein") for the ras oncogene.
The ras oncogene is an important target involved in many major tumors including colon and bladder.
In addition, Genentech has a broad and intensive effort in preclinical cancer research, including: anti-VEGF, which may inhibit blood vessel growth in tumors; the Ras oncogene, which may have the potential to stop uncontrolled cell division in certain cancers, such as pancreatic cancer; and thrombopoietin (TPO), which may be useful in treating the platelet destruction caused by irradiation and chemotherapy.
Kimmelman's research has focused on RAS oncogenes, one of the most commonly mutated families of cancer-causing genes.
For example, the RAS oncogenes are regulated by the let-7 family of miRNAs, and MIR155 and MIR gene clusters 17-92 are associated with the MYC [v-myc myelocytomatosis viral oncogene homolog (avian)] oncogene.
elegans and subsequently in human cells that let-7 regulates the RAS oncogenes through complementary sites in their RNAs' 3' UTRs.
Analysis of ras oncogenes in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype.
A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides.