ras gene


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Related to ras gene: p53, RB gene, Proto oncogene

ras gene

(răs)
n.
Any of several oncogenes that code for Ras proteins.
References in periodicals archive ?
The first group's work began with Ras genes, which are abnormal in half of all colon cancers, about 90 percent of pancreatic cancers, and smaller fractions of other human cancers.
In the April 3 SCIENCE, David Sidransky of Johns Hopkins University in Baltimore and his colleagues describe a stool test that detects mutations in the ras gene.
Other scientists working on ras genes are skeptical, or even incensed, by Duesberg's proposal.
By putting different combinations of the genes into yeast, the researchers determined that the RAS gene products regulate growth in yeast solely by modulating adenylate cyclase activity.
The ras genes code for 21-kDa proteins that mediate signal transduction between cell surface receptors and intracellular regulatory molecules.
A highly sensitive assay for mutant ras genes and its application to the study of presentation and relapse genotypes in acute leukemia.
Remarkably, the 3' UTRs of the 3 human RAS genes [HRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog), KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), and NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog)] contained multiple let-7--complementary sites, allowing let-7 to regulate RAS expression.
Ras genes (3 are known, H-, K-, and N-ras) encode small, 21-kd G proteins that mediate signals from many common growth-factor receptors.
He said: ''I am honoured to be given this prestigious award which recognises my work on Ras genes.
Papillary carcinomas carry point mutations of the BRAF and RAS genes as well as RET/PTC and TRK rearrangements, all of which are able to activate the mitogen-activated protein kinase (MAPK) pathway (Figure 1).
For example, PCP, has been used to detect mutant DNAs in neoplastic exfoliated cells; mutations have been detected in ras genes present in stool samples obtained from patients with colorectal cancel, and in p53 from the urine of patients with bladder cancer and in the sputa of patients with lung cancer.
With the advent of PCR-based detection of DNA from rare neoplastic cells in body fluids, mutations have been detected in ras genes from the stools of patients with colorectal cancer, in p53 from the urine of patients with bladder cancer, and in p53 genes in the sputum of patients with lung cancer.