The final goal is to identify the DNA target structures that can be most efficiently sensitized to low-energy electrons by radiosensitizers
However, pancreatic cancer tends to become radio-resistant to currently available radiosensitizers
Enhancing the Effectiveness of Cancer Therapy: Combining Radiosensitizers
and Radiation Therapy
Also, work on radiosensitizers
should begin to focus on preferentially affecting CSCs compared with normal tissues and normal tissue stem cells.
Their topics include radical reaction pathways initiated by direct energy deposition in DNA by ionizing radiation, the reactivity of nucleic acid sugar radicals, pyrimidine nucleobase radical reactivity, the kinetics of long-range oxidative electron transfer through DNA, electronic-affinic radiosensitizers
, principles and applications of electrochemical oxidation of nuclear acids, and DNA damage by phenoxyl radicals.
In some regimens, chemotherapeutic agents (such as the taxanes) are now used as radiosensitizers
to maximize the tumor-killing effect of radiation (140).
Screening for mutagenicity of nitro-group containing hypoxic cell radiosensitizers
using Salmonella typhimurium strains TA100 and TA98.
This database includes reactions of many compounds of industrial and biochemical interest, such as antioxidants, vitamins, dyes, photosensitizers, radiosensitizers
, radioprotectors, amino acids, and enzymes; and provides kinetic information on many unstable species of physiological and atmospheric importance.
Lacombe~s work focuses on improving the hadrontherapy performances using metal nanoparticles (NPs) as radiosensitizers
This drug pipeline update is structured around radiolabeled drugs, radiosensitizers
and radioprotective compounds.
1:00 pm - 5:00 pm - Poster Session Radiosensitizers
We are still formulating plans for clinical development, but PH-12 radiosensitizers
could be a good candidate for therapy used in conjunction with radiation to treat difficult visceral cancers, including pancreatic, lung or prostate cancer.