Gemcitabine and its metabolite, dFdU both are radiosensitizers
that easily cross the BBB and reach high concentrations within tumour cells.
Cannabis Sciences recent, peer-reviewed publication in Frontiers in Oncology, Nanoparticle Drones to Target Lung Cancer with Radiosensitizers
and Cannabinoids, in just a few months, has already been viewed more than 6,500 times, with the article having more views than 91% of the papers published in all Frontiers journals.
Radiotherapy and radiosensitizers
in the treatment of glioblastoma multiforme.
of TMZ can act like oxygen (25) and thus intensify lesion due to irradiation.
However, the radiosensitizers
most commonly used today (Cisplatin, 5-fluorouracil [5-FU], and taxanes) do have inherent cytotoxic activity and can increase damage to normal tissues, with a 'true' benefit achieved only if the increase in antitumor effect is larger than the normal tissue damage.
and Radiochemotherapy in the Treatment of Cancer
Results of various studies on WBRT with radiosensitizers
in brain metastases are varied and these agents will likely play increasingly important roles in the treatment of brain metastases3.
Enhancing the Effectiveness of Cancer Therapy: Combining Radiosensitizers
and Radiation Therapy
Also, work on radiosensitizers
should begin to focus on preferentially affecting CSCs compared with normal tissues and normal tissue stem cells.
Their topics include radical reaction pathways initiated by direct energy deposition in DNA by ionizing radiation, the reactivity of nucleic acid sugar radicals, pyrimidine nucleobase radical reactivity, the kinetics of long-range oxidative electron transfer through DNA, electronic-affinic radiosensitizers
, principles and applications of electrochemical oxidation of nuclear acids, and DNA damage by phenoxyl radicals.
Screening for mutagenicity of nitro-group containing hypoxic cell radiosensitizers
using Salmonella typhimurium strains TA100 and TA98.
This database includes reactions of many compounds of industrial and biochemical interest, such as antioxidants, vitamins, dyes, photosensitizers, radiosensitizers
, radioprotectors, amino acids, and enzymes; and provides kinetic information on many unstable species of physiological and atmospheric importance.